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An abnormally large immature red blood cell (erythroblast) found especially in the blood of people with certain types of anemia and often associated with vitamin B12 deficiency.

meg′a·lo·blas′tic adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Medicine) an abnormally large red blood cell precursor, present in certain types of anaemia
megaloblastic adj
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈmɛg ə ləˌblæst)

an abnormally large immature dysfunctional red blood cell found in the blood esp. of persons with pernicious anemia.
meg`a•lo•blas′tic, adj.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.megaloblast - abnormally large red blood cell present in pernicious anemia and folic acid deficiencymegaloblast - abnormally large red blood cell present in pernicious anemia and folic acid deficiency
erythrocyte, RBC, red blood cell - a mature blood cell that contains hemoglobin to carry oxygen to the bodily tissues; a biconcave disc that has no nucleus
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Photomicrograph of Megaloblastic Anaemia; aspirate shows Megaloblasts with Sieve-Like Chromatin and Giant Metamyelocyte (Leishman Stain 1000x).
Uchino, "Proliferation of megaloblasts in pernicious anemia as observed from nucleic acid metabolism," Blood, vol.
Megaloblastic anemia is an anemia that is characterized by the presence of precursor cells, megaloblast in the bone marrow and macrocytic red cells in the peripheral blood.4 These megaloblasts arise because of impaired DNA synthesis followed by ineffective erythropoiesis.4
Without the vitamin the red cells can become enlarged and will be immature and a strange shape (megaloblasts) and, as a consequence of this, they will be unable to marry with the oxygen-carrying Haemoglobin to deliver oxygen to wherever it is needed in the body--which is, incidentally, everywhere.
This leads to megaloblastic anaemia, in which large, abnormal red cells (megaloblasts) form in the bone marrow and production of normal red blood cells is curtailed.