melarsoprol


Also found in: Medical, Wikipedia.
Related to melarsoprol: Nifurtimox, Suramin, Eflornithine
Translations

melarsoprol

n melarsoprol m
References in periodicals archive ?
Pentamidine is the main drug used during the early stages of the human disease and melarsoprol is used when trypanosomes have invaded the central nervous system.
The HAT disease can be treated by using drugs such as suramin, eflornithine, melarsoprol, and pentamidine.
suramina sdica, melarsoprol, cloridrato de eflornitina para tratamento de tripanossomiase africana e vacina para encefalopatia japonesa, pois sao farmacos destinados ao tratamento de doencas nao prevalentes no pais; e vi.
Gyurasics, "Role of glutathione in the biliary excretion of the arsenical drugs trimelarsan and melarsoprol," Biochemical Pharmacology, vol.
TbAQP2 knockout cells also were found to be cross-resistant to melarsoprol and pentamidine (Baker et al., 2012).
evansi is based on antiprotozoal drugs such as suramine, diminazene aceturate, quinapyramine, melarsoprol and isometamidium (18).
In the 1940s, melarsoprol was introduced to treat the neurological phase, but it produces serious side-effects such as convulsions, coma and psychotic episodes in as many as 10% of people treated with it.
The currently available drugs for trypanosomiasis treatment include pentamidine (8), melarsoprol (9), and eflornithine (10).
brucei rhodensiense, Suramin 1 g intravenously on day 1, 3, 5, 14 and 21, is a drug of choice in haemolymphatic stage, while Melarsoprol 2-3.6 mg/ kg/day for three days (3 courses; 7 days apart) is suggested for CNS disease.
rhodesiense infection is treated with melarsoprol, a highly toxic arsenical which causes a severe reactive encephalopathy in -10% of patients, half of whom die as a result (10).
Once the disease has crossed the blood-brain barrier and entered the central nervous system the most commonly used treatment is an intravenous course of the arsenic-based drug melarsoprol.