Chlorpromazine (Thorazine), clozapine (Clozaril), methotrimeprazine (Nozinan), olanzapine (Zyprexa), perphenazine (Trilafon), pimozide (Orap), quetiapine (Seroquel), thioridazine (Mellaril
), and trifluoperazine (Stelazine).
* Extreme sensitivity to antipsychotic medications used to control behavioral symptoms in other types of dementia-such as haloperidol (Haldol) and thioridazine (Mellaril
)--resulting in worsening of movement disorders in people with DLB, and possibly kidney failure or even death.
Riggins informed the prison psychiatrist that he had successfully been treated in the past with Mellaril
(thioridazine), an antipsychotic medication, so the doctor prescribed him the same medication.
The only record of note carried from the pre-2004, written medical records is Panetti's allergies to three psychiatric drugs used to treat schizophrenia: Mellaril
, Thorazine and Haldol.
Typical antipsychotics Atypical antipsychotics Pimozide (Orap) Quetiapine (Seroquel) Chlorpromazine (Thorazine) Risperidone (Risperdal) Haloperidol (Haldol) Ziprasidone (Geodon) Thioridazine (Mellaril
) Mesoridazine (Serentil) Adapted from http://www.torsade.org/.
He had been heavily tranquilized on one of the older antipsychotics, Thorazine or Mellaril
, but he appeared capable of basic functioning and holding a job.
Antipsychotic Medications, Generic and Brand Names and Typical Tablet Dosage Generic Name Brand Name Tablet dosage range Atypical Risperidone Risperdal 1-3 mg Olanzapine Zyprexa 2.5-10 mg Clozapine Clozaril 25-100 mg Quetiapine Seroquel 25-200 mg Ziprasidone Geodon 20-60 mg Aripiprazole Abilify 5-15 mg High Potency Haloperidol Haldol 0.5-20 mg Typical Pimozide Orap 2 mg Fluphenazine Prolixin 2.5-10 mg Medium Potency Trifluoperazine Stelazine 1-10 mg Typical Perphenazine Trilafon 2-16 mg Thiothixene Navane 2-20 mg Loxapine Loxitane 5-50 mg Low Potency Molindone Moban 5-100 mg Typical Mesoridazine Serentil 10-100 mg Thioridazine Mellaril
10-200 mg Chlorpromazine Thorazine 10-200 mg Adapted from Wilens (1999) and Li, Pearrow, & Jimerson (2010).
Riggins began taking mellaril
prior to the trial, but requested it be stopped during trial because of its effect on his demeanor and his mental state.
not contend that he had a right to be tried without Mellaril
Medications Associated with Changes in Urine Color Color of urine Medications red senna (Ex-Lax), chlorpromazine (Thorazine), thioridazine (Mellaril
) orange rifampin (Rifadin), warfarin (Coumadin), phenazopyridine (Pyridium) blue or green amitriptyline (generic), indomethacin (Indocin), cimetidine (Tagamet), promethazine (Phenergan) dark brown or tea-colored chloroquine (Aralen), primaquine (generic), metronidazole (Flagyl), nitrofurantoin (Furadantin)
(With these patients, drugs on Class 1, 2 and 4 should also be avoided) amiodarone, biaxin chloral hydrate, cocaine as local chloroquine, indapamide, lithium, anaesthetic, dexatrine, chlorpromazine serevent, ventolin, dobutamine, dopamine, cisaprid, zithromax ephedrine, epinephrine, clarithromycin, levophed, appetite disopyramide, suppressant phentermine, domperidone, haldol, dexatrim[R], acutrim[R], mellaril
, methadone, sibutramine, ritilin, procainamide, ventolin sotalol Class 1: Drugs that Class 4: Drugs that are weakly are accepted by associated with TdPand/or QT authorities to have prolongation but are unlikely to be a risk of prolonging a risk for TdP when used in usual QT interval and TdP recommended dosages and in patients without other risk factors *.
* Anti-psychotics, such as haloperidol (Haldol), thioridazine (Mellaril
), thiothixene (Navane)