An increase in the urinary levels of two pyrethroid metabolites
(3-PBA and cis-DBCA) in children is associated with a significant decrease in their cognitive performances , particularly verbal comprehension and working memory.
Enormous amounts of information can be gleaned from comprehensively characterizing thousands of the chemical byproducts of metabolism called metabolites
High-throughput identification and quantification of small molecule metabolites
produced by metabolism, or metabolomics, is increasingly used to evaluate alterations in metabolism and their relationship to human disease (1-5).
Recent research into metabolites
of curcuminoids has found that it is not the curcumin, but its metabolite
, tetrahydrocurcumin, that is responsible for biological function in the body.
Samples of first-morning urine were collected and assessed for three metabolites
of low-molecular-weight phthalates (commonly used in personal care products) and eight metabolites
of high-molecular-weight phthalates (commonly used in PVC applications such as flooring, electrical cords, car interiors, and toys).
Several lines of evidence suggest that rutin, flavonoid in fruits and vegetables, or one of its metabolites
may effectively modulate advanced glycation end product (AGE) formation.
are of interest because the presence and concentrations of some of them can provide meaningful profiles, sometimes referred to as "metabolic signatures" or "fingerprints.
They identified more than 600 liver-originated metabolites
, which are the chemical substances created by metabolism that sustain and promote cell health and growth.
For example, for steroids like Stanozolol or Nandrolone, the parent compound is not detected in a urine sample or reported by the laboratory, but the steroids' metabolites
Recent improvements in LC-MS resolution, mass accuracy and sensitivity have enabled a new generation of instruments to analyse more complex mixtures and identify the metabolites
and sites where metabolism occurs.
Using Symyx Metabolite
's structure-searchable metabolic schemes, biotransformation explorer, and easy-to-use query and browse tools, scientists can quickly explore the fate of parent compounds, their metabolites
, and properties by leveraging in-house and Symyx database information.
The body breaks down inhaled 1-NP into several smaller molecules, called metabolites
, that show up in urine.