Pharmacokinetic properties of common uterotonics used to reduce postpartum bleeding Half-life Storage Oxytocin 1 to Cold storage 6 minutes Misoprostol 20 to Stable at ambient 40 minutes temperature Ergonovine 30 to Cold storage (ergonovine) 120 minutes Methylergonovine 1.5 to Cold storage (Methergine
) 13 hours Carboprost 8 minutes Cold storage (Hemabate) 15- methyl prostaglandin F2 alpha Carbetocin (not 40 minutes Stable at available in ambient the United temperature States) Oxytocin With intravenous bolus With intramuscular or infusion, onset of injection the onset action is achieved of action is within within 1 minute.
She then presented at another hospital near her home 2 days later and received additional treatment (methergine
(*) and uterine reaspiration).
Amneal also received approval for a generic version of Methergine
tablets USP, 0.2 mg (methylergonovine maleate tablets USP, 0.2 mg), which it expects to launch shortly.
In addition, the company plans to market the approved generic version of Methergine
Tablets USP, 0.2 mg (Methylergonovine Maleate Tablets USP, 0.2 mg ) shortly.
The company also received approval for a generic version of Methergine
Tablets USP, 0.2 mg, which it expects to launch shortly.
2) Ergometrine (methergine
): Ergot alkaloids exert various effects throughout the body on at least three different types of receptor.
The acquisition of Symbiomix and the Solosec franchise expands Lupin's branded women's health specialty business, which is presently anchored by Methergine
, Misoprostol and Prostaglandin (PGF2a) have been used in different studies, claiming advantages, efficacy and side effects of one or the other with regards to reduction of blood loss, shortening of duration of 3rd stage of labour, reduction in the incidence of PPH and side effects.
Simultaneously, oxytocics should be administered as well as methergine
and prostaglandin F2a.
The patient required doses of both carboprost tromethamine (Hemabate) and methylergometrine (Methergine
) to increase uterine tone and control bleeding.
Decadron injection, Methergine
, New Mercazole tabs and many other drugs are not available in the market, he informed.
Intramuscular methylergonovine maleate (Methergine
) is sometimes used to treat uterine atony but should not be used in women with hypertension because of vasoconstrictive properties (King & Brucker, 2011).