methotrexate

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meth·o·trex·ate

 (mĕth′ə-trĕk′sāt)
n.
A folate antagonist, C20H22N8O5, that inhibits DNA synthesis and is used to treat psoriasis, certain cancers, and some inflammatory diseases such as rheumatoid arthritis. It is sometimes used in combination with misoprostol to induce abortion in early pregnancy.

[methotre- (probably shortening and alteration of methylaminopterin, one of its chemical names : methyl + aminopterin) + perhaps (o)x(y)- + -ate.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

methotrexate

(ˌmɛθəʊˈtrɛkseɪt; ˌmiːθəʊ-)
n
(Pharmacology) an antimetabolite drug used in the treatment of certain cancers. Formula: C20H22N8O5
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

meth•o•trex•ate

(ˌmɛθ oʊˈtrɛk seɪt)

n.
a toxic folic acid analogue, C20H22N8O5, that inhibits cellular reproduction and is used in the treatment of psoriasis and certain cancers.
[1950–55; metho (xy)- + trexate, of unclear derivation]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.methotrexate - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations

methotrexate

n metotrexato, metotrexate m
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
The patient was started on albendazole (400 mg 2x/d orally) and cyclosporine (100 mg 2x/d orally); tacrolimus and methrotrexate were ceased, and the prednisone dosage was reduced.
Several drugs, and in particular amiodar-one, bleomycin, busulfan, methrotrexate, nitrofurantoin, may also induce the PF.
However, administration of methrotrexate may lead to accelerated placental destruction with accumulation of necrotic tissue and ultimately infection and abscess formation, and we therefore avoided it.