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Related to Methysticin: Kavalactones


n.1.(Chem.) A white, silky, crystalline substance extracted from the thick rootstock of a species of pepper (Piper methysticum) of the South Sea Islands; - called also kanakin.
References in periodicals archive ?
The bioactive chemical constituents from Kava are the kava lactones, particularly kavain, dihyd rokava in, yangonin, dimethoxyyangonin, methysticin and dihydromethysticin (Fig.
The active constituents (secondary metabolites) are the fat soluble kava lactones (kavapyrones), and the main compounds are methysticin, dihydromethisticin, kavain, dihydrokavain and desmethoxyangonin and flavonoids (flavokavains) (Braun 2007).
0mg/ml/kg), Piper methysticum extract (containing 30% kavalactones), kavain, dihydrokavain, methysticin, dihydromethysticin, yangonin, or desmethoxyyangonin, (30mg/ml/kg for kava compounds) 30 minutes prior to being tested in the presence of two conspecifics or in isolation for a three minute observation period.
There are six major kavalactones in kava: yangonin, methysticin, kavain, dihydromethysticin (DHM), dihydrokavain and demethoxy-yangonin.
Yangonin, demethoxyyangonin, methysticin, dihy-dromethysticin, kavain, and dihydrokavain were identified in the largest peaks, accounting for 96% of the total kavalactones.
1997; Lebot 2006; Schmidt 2007; WHO 2007): kavain (K), dihydrokavain (DHK), methysticin (M), dihydromethysticin (DHM), yangonin (Y), and desmethoxyyango-nin (DMY).
Methysticin, dihydromethysticin, kavain and dihydrokavain were detected at 240 nm, demethoxyyangonin and yangonin at 360 nm.
Ethanolic kava extract and the kavalactones methysticin, yangonin, and desmethoxy-yangonin were previously shown not to be activated to toxic metabolites in cultured human lymphoblastoid MCL-5 cells stably transfected with human cytochrome P450 enzymes (1A1, 1A2, 2A6, 2E1, 3A4) and human epoxide hydrolase (Zou et al.
Four kavalactones, ([+ or -])-kavain, methysticin, yangonin and desmethoxyyangonin, fail to inhibit ADH in vitro at 1, 10 or 100 [micro]M concentrations.
Method: HPLC determination (normal phase) against desmethoxy-yangonin, dihydrokawain, yangonin, kawain, dihydromethysticin, methysticin as reference substances (test specification no.
Methysticin was the most potent enzyme inhibitor as well as the most cytotoxic, followed by (in order of potency:) the kava root extract, desmethoxyyangonin, and yangonin.
Backhauss C, Krieglstein J (1992) Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents.