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 (mī′krō-glē′ə, -glī′-)
Small neuroglial cells of the central nervous system that have long processes and act as phagocytes at sites of neural damage or inflammation, destroying pathogens and damaged cells.

mi′cro·gli′al adj.


(Anatomy) one of the two types of non-nervous tissue (glia) found in the central nervous system, having macrophage activity. Compare macroglia
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.microglia - neuroglial tissue of mesodermal origin that can become phagocyticmicroglia - neuroglial tissue of mesodermal origin that can become phagocytic
glia, neuroglia - sustentacular tissue that surrounds and supports neurons in the central nervous system; glial and neural cells together compose the tissue of the central nervous system
microgliacyte - a cell of the microglia that may become phagocytic and collect waste products of nerve tissue
References in periodicals archive ?
Fractalkine is essential for microglial cell migration.
Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated activation of murine N9 microglial cell line.
Histopathological changes: In brain microglial cell numbers were increased and aggregated to form microglial nodules andneurophagia phenomena was observed (Fig 3A).
Caption: In this 3-D reconstruction, a microglial cell (red) engulfs synapses (green) in a mouse's hippocampus after an injection of the Alzheimer's-related protein amyloid-beta.
Lokensgard, "Herpes simplex virus induces neural oxidative damage via microglial cell Toll-like receptor-2," Journal of Neuroinflammation, vol.
Additional genes related to cell migration (PTK2B), lipid transport and endocytosis (SORL1) also were confirmed, and new hypotheses emerged related to hippocampal synaptic function (MEF2C, PTK2B), the cytoskeleton and axonal transport (CELF1, NME8, CASS4), as well as myeloid and microglial cell functions (INPP5D).
Autopsy studies and animal experiments suggest that microglial cell inflammation is involved in inducting the pathogenesis of motor neurons and their death in ALS.
Therefore, quantification at a high spatial and temporal resolution of ROI distribution in the microenvironment of an activated microglial cell is important for the assessment of neurotoxicity.
The BV-2 microglial cell line was obtained as a gift from by Dr.
Protein markers of neuronal death (GFAP) and microglial cell activation (ALBU); heat shock proteins that act as protein chaperones (e.
AD which is resulted from neuronal loss and atrophy particularly in temporo parietal andfrontal cortex with an inflammation response to the deposition of amyloid plaque and abnormal cluster of protein fragments and tangled bundles of fibres (neurofibrillary Tangles-NFT) and also increased presence of monocytes or macrophages in cerebral vessel wall and reactive or reactivated microglial cell in theparenchyma (1,2) along with decrease level of neurotransmitter (NT)-Acetylcholine
In vitro studies using steroids have shown inhibition of both microglial cell proliferation and activity of NO synthase (68) in the isolated microglial cells.