are recently discovered, naturally occurring, small RNAs that act as master regulators and have the potential to form the basis for a new class of diagnostics and therapeutics.
This is a groundbreaking study shedding light on the critical role microRNAs
play in fighting cancer and highlights their potential to act as novel drug targets," noted Dr.
elegans, researchers have discovered a class of natural small RNA molecules called microRNAs
that appear to be crucial in regulating development.
His laboratory focuses on understanding the molecular mechanisms of gene regulation by microRNAs
and how microRNAs
function in regulatory networks affecting development and disease.
5 August 2014 - US Regulus Therapeutics (NASDAQ:RGLS), a developer of drugs targeting microRNAs
, said Tuesday it had partnered with Biogen Idec Inc (NASDAQ:BIIB) to detect microRNAs
as biomarkers for multiple sclerosis (MS) under its Regulus microMarkers division.
The researchers identified 13 unique microRNAs
that were highly altered by THC.
are known to play critical roles in cell development as well as a number of diseases, including cancer.
are small fragment of RNA (20-50nt) that regulates gene expression.
No one would have predicted a decade ago that these microRNAs
, as the hairpins are called, were involved in cancer, because no one even knew that they existed in people.
Rosetta Genomics is a leader in the field of microRNAs
have emerged as an important class of small RNAs encoded in the genome.
To determine which patients were most likely to have a response to temozolomide, the research team investigated microRNAs
controlling the expression of the protein, methyl-guanine-methyl-transferase (MGMT), which reduces the cancer-killing effect of temozolomide.