This and similar illustrations or explanations are put forth, not for their own sake, or as an exposition of Plato's theory of ideas, but with a view of showing that poetry and the mimetic
arts are concerned with an inferior part of the soul and a lower kind of knowledge.
In saying this, I intended to imply that we must come to an understanding about the mimetic
art,--whether the poets, in narrating their stories, are to be allowed by us to imitate, and if so, whether in whole or in part, and if the latter, in what parts; or should all imitation be prohibited?
Our innovation consists of a stage upon which we place cell membranes or mimetics
, a jet of solvent is directed at the membranes and an inlet samples the particles, producing a stream of charged particles for study in a mass spectrometer.
Therefore, it makes sense to rethink the conceptual foundations of design mimetics
in this new technological era.
Research has suggested that CR and specific foods that have been dubbed as 'calorie restriction mimetics
' are a major contributor to the longevity and low rates of disease that Okinawans face.
Huang et al.; "Glycocalyx Remodeling with Proteoglycan Mimetics
Promotes Neural Specification in Embryonic Stem Cells"; Journal of the American Chemical Society, 2014; 136 (30): 10565 DOI:10.1021/ja505012a
Roughly 15% of patients started sulfonylureas, 3% took thiazolidin ediones, 78% were on metformin, 3% took DPP-4 inhibitors, 1% were on incretin mimetics
, and 1% took meglitinides.
Part II then discusses synthesis and particular mimetic
molecules in more detail, including bioisosteres, solid-phase synthesis, combinatorial approaches, click chemistry with triazole scaffolding, peptoids, sugar amino acids as scaffolds, cyclic alpha-amino acids as proline mimics, beta-turn mimetics
, and foldamers, including material on both structure-function relationships and synthesis.
ABT-737 is one of a new class of anti-cancer agents called BH3 mimetics
that target and neutralise the so-called Bcl-2 proteins in cancer cells.
Yeaman and Yount are now translating the motif into peptide mimetics
and small molecules, and are designing so-called modular anti-infectives with customized payloads of drugs that attach to the [gamma]-core motif.
Amanda eloquently describes herself as "Gene-tweaked, adolescence plateau extended, super-oxide dismutase mimetics
. telomerase transducers, developmental cascade inhibited until Maturity." (She speaks to imitate artificial intelligence and does not use connector words-it's all the rage at the mall.) She won't reach Maturity until age 30, two years away.
The invention also relates to the therapy of human cancers which have a mutation in the CDC14A gene, including gene therapy, protein replacement therapy and protein mimetics
. The invention further relates to the screening of drugs for cancer therapy.