At the same time, he noted that "hyper-sexuality" is a "well-established and common impulse control disorder" among Parkinson's patients who take a class of drugs known as dopamine agonists, which include pramipexole (Mirapex
) and ropinirole (Requip).
His bradykinesia, rigidity, intention tremor and postural hypotension continued to progress despite escalating doses of Sinemet (Carbidopalevodopa), Mirapex
(Pramipexole), and Symmetrel (Amantadine).
These results supported a revision of the Mirapex
IR Prescribing Information approved by the FDA in March 2013, which remains in the most recent 2016 version .
Dopaminergic Parkinson's disease medications, such as pramipexole (mirapex
) and ropinirole (requip), are known to cause orthostatic hypotension (Nolden et al., 2014).
The most common drugs in this category used for sleep, specifically movement disorders, include Sinemet (levodopa/carbidopa), dopamine agonists such as Requip (ropinirole), and Mirapex
(pramipexole) both FDA approved for restless legs in recent years.
Pramipexole Dihydrochloride Tablets, the generic version of Mirapex
, is available in 0.125-, 0.25-, 0.5-, 0.75-, 1- and 1.5-milligram 90-count bottles.
DAs, such as ropinirole (Requip, Repreve, Ronirol, Adartel) and pramipexole (Mirapex
, Mirapexin, Sifrol), are chemicals that act on the postsynaptic terminals within the striatum and activate the postsynaptic receptors to reduce dopamine turnover (Hristova & Roller, 2000).
Pramipexole dihydrochloride tablets, the generic version of Mirapex
, is available in 0.125, 0.25, 0.5, 0.75, 1 and 1.5 mg 90-count bottles and is used to treat the signs and symptoms of Parkinson's disease as well as treating restless legs syndrome (RLS).
The company said the PRAMIPEXOLE dihydrochloride extended-release tablets 0.375 mg, 0.75 mg, 1.5 mg, 3 mg and 4.5 mg is the therapeutic equivalent generic version of MIRAPEX
ER (pramipexole dihydrochloride) Extended-Release Tablets.
The increased levodopa dosages before the surgeries were as follows: BHL 1# QID, Mirapex
0.5# OID, Requip 1# BID, Stalevo 1# QID.