mitochondrial disease

(redirected from Mitochondriopathy)
Also found in: Medical.

mitochondrial disease

n.
Any of various diseases caused by malfunctioning of mitochondria as a result of inherited or acquired mutations in mitochondrial or nuclear DNA, typically affecting several organ systems, especially the nervous and muscular systems.
References in periodicals archive ?
COQ2 nephropathy: A newly described inherited mitochondriopathy with primary renal involvement.
Zhu et al., "Mitochondriopathy of peripheral arterial disease," Vascular, vol.
(2015) Loss of function variants in human PNPLA8 encoding calcium-independent phospholipase [A.sub.2][gamma] recapitulate the mitochondriopathy of the homologous null mouse.
Several presumed mechanisms of activity of cell therapy in CLI have been reported by previous studies; these include (i) increased tissue vascularity; (ii) increased tissue microperfusion at the capillary level; (iii) remodelling of fibrotic tissues to allow new capillary growth or increase interstitial fluid flow; (iv) improved mitochondriopathy; and (v) modulation of the inflammatory response program from tissue destruction to wound healing.
Patients with movement disorders had a screening for Wilson's disease (serum ceruloplasmin test; serum and urine copper tests) and mitochondriopathy (lactate in serum and CSF) and some patients had screening for NMDA antibodies and streptolysin O antibodies.
MT-ATP6:G167S mutation, a candidate for the etiologic factor of a particular mitochondriopathy, is found in both patients and healthy individuals.
This chronic ischemia leads to mitochondriopathy of PAD muscle and is linked to oxidative damage to the muscle components [30] and axonal nerve loss [39].
The development of neurodegeneration in MS is a complex process that may be related to primary apoptosis, synaptopathy, and excitotoxicity associated with glutamate overload, ionic channel dysfunction, calcium overload, mitochondriopathy, proteolytic enzyme production, and activation of apoptotic pathways.
The multifold range of involved include hormone and neurotransmitter, oxidation-reduction, mitochondriopathy, detoxification, biotransformation, immune response, inflammation, and digestive, microbiological, and structural imbalances from cellular membrane function to the organ systems.
Nicotinamide adenine dinucleotide (NAD) deficiency is an integral part of mitochondriopathy. (36,38-40) Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells.
Keywords: Inborn errors of metabolism, Methylmalonic acidaemia, Mitochondriopathy, Non-ketotic hyperglycinaemia, Fructose 1, 6 diphosphatase deficiency.
Muscular exercise, claudication and other discomforts, intrinsic pathology of PAD (ischemia and mitochondriopathy), the presence of multiple comorbidities such as diabetes and heart disease, advanced age, and physical deconditioning/inactivity (1) all likely contribute to the changes in cardiovascular responses to exercise.
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