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Any of a group of antibiotics produced by the soil actinomycete Streptomyces caespitosus that inhibit DNA synthesis and are used against bacteria and cancerous tumor cells.

[Probably mito(sis) + -mycin.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Pharmacology) pharmacol any of the antibiotics that come from Streptomyces caespitosus
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.mitomycin - a complex of antibiotic substances obtained from a streptomyces bacterium; one form (trade name Mutamycin) shows promise as an anticancer drug
antibiotic, antibiotic drug - a chemical substance derivable from a mold or bacterium that can kill microorganisms and cure bacterial infections; "when antibiotics were first discovered they were called wonder drugs"
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References in periodicals archive ?
The superiority of any of the IVCT agents (mitomycin C, epirubicin, pirarubicin, and thiotepa) to one another has yet to be demonstrated (29).
Results of the phase I trial of cetuximab with mitomycin c and 5-fluorouracil concurrent with radiotherapy treatment in patients with muscle-invasive bladder cancer.
Mitomycin C is a substance isolated from the bacterium Streptomyces caespitosus, which is used as a chemotherapeutic agent and has antiproliferative effects on fibroblasts, reducing fibroblast proliferation and collagen formation.
Her medical history included right breast invasive ductal carcinoma with bilateral mastectomies in 2015, recently diagnosed bladder cancer with TURBT and intravesical mitomycin C instillation three days prior to current presentation, type 2 diabetes mellitus, hypertension, obstructive sleep apnea, chronic obstructive pulmonary disease, and prothrombin G20210A mutation.
A randomized trial comparing mitomycin C and conjunctival autograft after excision of primary pterygium.
Effectiveness of mitomycin C in reducing reformation of adhesions following surgery for restrictive strabismus.
This treatment protocol is easy to perform with possible lower costs and side effect rate if compared with the application of mitomycin C. Moreover, the selection of a bare scleral procedure associated with subconjunctival bevacizumab injections as a first-step treatment may prevent the complications associated with other surgical techniques that can still be easily applied, at a later time, in case of failure of the first approach or widesized postoperative defects.
The American Society of Peritoneal Surface Malignancies evaluation of HIPEC with mitomycin C versus Oxaliplatin in 539 patients with colon cancer undergoing a complete cytoreductive surgery.
(2) They conducted a randomized, prospective study of 224 patients with primary low- to intermediate-risk tumours (TaT1, G1/G2)--113 were assigned 18-22 hours of CSBI and 111 received immediate installation of mitomycin C following TURB.
Methods: This is a cross sectional study which included 145 eyes of 74 patients in 18 to 51 years age group that were undergoing Photorefractive keratectomy with mitomycin C using Allegretto Wave Eye-Q 400-Hz excimer laser platform in Markazi Eye Center, Tehran, Iran.
Inhibitory effect of mitomycin C on proliferation of primary cultured fibroblasts from human airway granulation tissues.