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Noun1.monoblast - a large immature monocyte normally found in bone marrowmonoblast - a large immature monocyte normally found in bone marrow
monocyte - a type of granular leukocyte that functions in the ingestion of bacteria
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Peripheral blood smear revealed 80% monoblasts. Bone marrow aspiration revealed an 80-90% blastic infiltration with suppressed erythropoiesis and megakaryopoiesis.
Flow cytometry analysis indicates the blasts are CD34~, CD117~, CD13~, CD33+, CD14~, CD64+, CD56+, HLA-DR+, and CD123+, consistent with monoblasts. B, Bone marrow core is replaced by sheet of blasts with folded nuclei and dispersed chromatin (Wright-Giemsa, original magnification X1000 [A]; hematoxylin-eosin, original magnification X600 [B]).
* denotes myeloblasts, thin arrows denote the monoblasts, and thick arrows denote promonocytes.