To the Editor: The unicornuate uterus arises from the anastomotic failure of the paired Mullerian ducts
in which simultaneously either of them is underdeveloped or absent, termed the 'rudimentary horn'.
Interaction of cells of Wolffian duct and mesothelium during initial growth period of mullerian ducts
in the axolotl (Ambystomamexicanum).
Anti-Mullerian hormone, a glycoprotein produced by Sertoli cells of the fetal testis around the 7th week of gestation, causes the regression of Mullerian ducts
and prevents the formation of female genitalia (uterus and fallopian tubes).
Uterine didelphys happens due to fusion failure of the Mullerian ducts
. Early high-level obstruction of the pelviureteric junction leading to agenesis of the ipsilateral kidney, often results in defects in the Mullerian duct
at the same level.
is a congenital malformation of the Mullerian ducts
, resulting in an absent uterus and variable degrees of hypoplasia of the fallopian tubes, cervix, and first two-thirds of the vagina.
cysts are focal failure of regression and saccular dilatation of the embryological mullerian ducts
The Mullerian ducts
, which form the majority of the female genitourinary tract, normally disintegrate in males under the influence of anti-Mullerian hormone .
Mullerian malformations are frequently associated with urinary malformations due to the intimate relationship between the mullerian ducts
and the Wolff ducts during the embryonic period.
A unicornuate uterus with a rudimentary horn is an anomaly caused by defective fusion of one of the paired Mullerian ducts
. The incidence of rudimentary-horn pregnancy is estimated to be one in 76,000 pregnancies.1 Life-threateningly heavy bleeding and abortion are the anticipated outcomes of rudimentary horn pregnancies.2,3
AMH is secreted from immature Sertoli cells in males and from ovarian granulosa cells in females and is responsible for the regression of the Mullerian ducts
in the male fetus.
Sertoli cells also ensure regression of mullerian ducts
via secretion of anti mullerian and inhibin hormones (3).
Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a rare anomaly in females that affects 1 in 5000 live births (1,2), in which there is dysgenesis of the Mullerian ducts
leading to failure of development of the uterus and vagina.