"Mesenchymal Stem Cells expand using the BD Mosaic hMSC SF cell culture environment and reliably retain their multipotency
, even after many passages."
Lee, "Importance of Sox2 in maintenance of cell proliferation and multipotency
of mesenchymal stem cells in low-density culture," Cell Proliferation, vol.
The slow, inertial flow also reduces stress on the cells, resulting in a high percentage (more than 90 percent) of viable cells with preserved multipotency
"In this study, we looked at SOX2's role in cells of the peripheral nervous system and discovered that it's required to sustain multipotency
, the ability to differentiate into several cell types in the peripheral nervous system, including neurons and glia," said Dr.
Stemness is one of the distinct features of stem cells from differentiated cells, which control the size of seed cell pool and the multipotency
of seed cells for skeletal regeneration.
To test whether the cells would maintain their multipotency
in living animals, the researchers transplanted them into mice whose white blood cells had been depleted.
Prolonged in vitro culture of bone marrow-derived MSCs leads to a loss of MSC phenotype, multipotency
, decreased wound homing properties , and self-renewal by around passage 15-20, associated with the onset of cellular senescence [33-36].
The results also revealed that GBP-L caused to no alteration in the multipotency
of the MSCs or loss of new bone forming.
Fotia and colleagues  reported that hypoxia enhances ADMSC proliferation and maintains the multipotency
status, allowing the differentiation in specific lineages in the presence of proper factors.
of the cells suggests their use in a variety of therapies.
Mesenchymal stem cells (MSCs) possess clonogenicity, multipotency
, and high proliferative capacity.
The bone marrow is the best source of stem cell but adipose-derived mesenchymal stem cells (ASCs) can be the alternative source in the clinical field, as both show similar characteristics regarding morphology, proliferation, multipotency
, and some specific markers [6, 7].