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A highly toxic alkaloid, C9H20NO2, found in fly agaric and certain other mushrooms. When ingested, it binds to acetylcholine receptors and thus stimulates the parasympathetic nervous system.

[New Latin muscāria, specific epithet (from feminine of Latin muscārius, of flies, from musca, fly) + -ine.]

mus′ca·rin′ic (-rĭn′ĭk) adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


1. (Physiology) of, relating to or resembling muscarine or its physiological action
2. (Physiology) (of a receptor) able to respond to muscarine
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice.
The muscarinic acetylcholine receptors are drug targets for neurodegenerative diseases.
However, the fact that atropine, an antagonist of muscarinic acetylcholine receptors (18), did not modify the direct vasorelaxation produced by clobenzorex on rat aortic segments excludes the possible involvement of stimulation of muscarinic acetylcholine receptors in the vasodilator responses produced by this appetite suppressant drug.
The other 21 target genes, such as acetylcholinesterase (ACHE), pancreatic alpha-amylase (AMY2A), and muscarinic acetylcholine receptor M3 (CHRM3), did not show above average mRNA expression in the 17 organs.
Matsumoto, "Anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjoogren's syndrome," Modern Rheumatology, vol.
(1983) Affinity chromatography of the muscarinic acetylcholine receptor. J.
Gyorgy et al., "A peptide of human muscarinic acetylcholine receptor 3 is antigenic in primary Sjogren's syndrome," Journal of Autoimmunity, vol.
This anticholinergic agent, which blocks the muscarinic acetylcholine receptor in the lung and reduces mucus secretion without systemic absorption or side effects, is useful in those with moderate and severe asthma when given along with the first nebulized dose of a bronchodilator such as albuterol, Dr.
KarXT (Karuna-Xanomeline-Trospium), Karuna's lead product candidate for the treatment of psychosis in schizophrenia, consists of xanomeline, a novel muscarinic acetylcholine receptor agonist that has demonstrated efficacy in placebo-controlled human trials in schizophrenia and Alzheimer's disease, and trospium chloride, an FDA-approved and well-established muscarinic receptor antagonist that has been shown not to enter the central nervous system.
Scopolamine (SCO) is a muscarinic acetylcholine receptor (mAChR) antagonist which disturbs learning and memory function in animals and humans similar to those conditions observed in the patients with AD [3].
When ACh is released into the nerve synapse, this neurotransmitter binds two distinct receptors on the postsynaptic cell: the ionotropic nicotinic acetylcholine receptor (nAChR) and the metabotropic muscarinic acetylcholine receptor (mAChR), which are bonded to G protein.