genetic load

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genetic load

n.
1. The relative difference between the theoretically most fit genotype within a population and the average genotype.
2. The aggregate of deleterious genes that are carried, mostly hidden, in the genomes of a population and may be transmitted to descendants.

genet′ic load′


n.
the extent to which a population deviates from the theoretically fittest genetic constitution.
[1965–70]
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References in periodicals archive ?
The mother is asymptomatic as her mutation load is only 24.
But because these signatures are found in many kinds of cancers, it isn't clear why smoking ups the mutation load.
However, in some families, oligosymptomatic children share the same mutation load as those of symptomatic siblings (Enns et al.
Recent advances in high-throughput sequencing technology have enabled associations between specific gene abnormalities and the somatic mutation load to be investigated in human cancer.
Mutation load can vary among tissues (including oocytes) in an individual and within a family.
Molecular pathology of MELAS and MERRF: the relationship between mutation load and clinical phenotypes.
Heretofore the determination of mutation load by measuring mitochondrial DNA heteroplasmy <10% has required more involved procedures, such as cloning and sequencing.
MELAS and MERRF: The relationship between maternal mutation load and the frequency of clinically affected offspring.
Tumor sidedness is a surrogate for differences in tumor biology and mutation load, potentially providing physicians with another means to help inform the treatment decisions for patients with metastatic colorectal cancer.
On the basis of these observations, we developed a quantitative DHPLC method to study mtDNA mutation load.
My hunch is that the higher mutation load results in a higher rate of generation of reactive oxygen species or other toxic byproducts of respiration, but that will need to be painstakingly tested," says Jacobs.