The mother is asymptomatic as her mutation load
is only 24.
But because these signatures are found in many kinds of cancers, it isn't clear why smoking ups the mutation load
However, in some families, oligosymptomatic children share the same mutation load
as those of symptomatic siblings (Enns et al.
Recent advances in high-throughput sequencing technology have enabled associations between specific gene abnormalities and the somatic mutation load
to be investigated in human cancer.
can vary among tissues (including oocytes) in an individual and within a family.
Molecular pathology of MELAS and MERRF: the relationship between mutation load
and clinical phenotypes.
Heretofore the determination of mutation load
by measuring mitochondrial DNA heteroplasmy <10% has required more involved procedures, such as cloning and sequencing.
MELAS and MERRF: The relationship between maternal mutation load
and the frequency of clinically affected offspring.
and the survival of small populations.
Tumor sidedness is a surrogate for differences in tumor biology and mutation load
, potentially providing physicians with another means to help inform the treatment decisions for patients with metastatic colorectal cancer.
On the basis of these observations, we developed a quantitative DHPLC method to study mtDNA mutation load
My hunch is that the higher mutation load
results in a higher rate of generation of reactive oxygen species or other toxic byproducts of respiration, but that will need to be painstakingly tested," says Jacobs.