APTO-253 is the only known clinical-stage molecule that directly can inhibit expression of the MYC oncogene
, shown to contribute to drug resistance in many malignancies.
In the postdoctoral fellows' category, Dr Yasser Majeed was first with a poster titled 'Sirt1 Deacetylase and Myc Oncogene
Interaction as a Regulator of Adipogenesis'.
A novel small molecule, APTO-253 inhibits expression of the MYC oncogene
, leading to apoptosis in human-derived solid tumor and hematologic cancer cells without the myelosuppression seen with other chemotherapies.
FISH analysis was indicative of a MYC oncogene
rearrangement, commonly associated with Burkitt lymphoma.
Treatment of GC at advanced stages remains difficult, and the prognosis is still poor, partly as a result of local recurrence, tumor invasion, and/or metastasis  The MYC oncogene
, located at 8q24, is a key oncogene in gastric carcinogenesis, and an increase in both copy number and mRNA expression was classified as one of the driver mutations in gastric tumors .
Leon, "MYC oncogene
in myeloid neoplasias," Clinical & Translational Oncology, vol.
Studies have shown that Epstein-Barr virus (EBV) infection and eight chromosome MYC oncogene
translocations were involved in the pathogenesis of BL.
The myc oncogene
has prognostic significance when its expression is altered by gene rearrangement, as these often involve the promoter regions of immunoglobulin heavy or light chain genes, leading to overexpression in and proliferation of malignant B-cells [4-6].
Molecular studies in radiation-associated sarcomas have revealed common inactivation of the p53 pathway and expression and amplification of the MYC oncogene
at the 8q24 region.