Born with Down syndrome, Ebrahim was diagnosed in June last year with acute myeloid leukaemia (AML), a type of cancer where the bone marrow makes abnormal myeloblasts
, a type of white blood cell, red blood cells or platelets.
Blasts look like either lymphoblasts or myeloblasts
and present as monomorphic medium-sized cells with irregular nuclei, one or more prominent nucleoli, and scant cytoplasms.
Clinical and laboratory features of seven patients with acute myeloid leukemia (AML)-M2/M3 and elevated myeloblasts
and abnormal promyelocytes.
Acute Myeloid Leukemia, the most common acute leukemia (blood and bone marrow cancer) in adults, is characterized by the proliferation of abnormal myeloblasts
(a type of white blood cell) in the bone marrow.
A type of cancer in which the bone marrow makes abnormal myeloblasts
, red blood cells or platelets, it is a slowly progressing disease that manifests itself in middle-aged people, rarely afflicting children.
BM Aspirate from a patient with Acute Myeloid Leukaemia showing Myeloblasts
. Leishman Stain x40
Further, 42% of his bone marrow cells were myeloblasts
with folded nuclei, prominent nucleoli, narrow cytoplasm, no granules, and no Auer rods.
A 71-year-old female with a history significant for hypertension, hepatitis B, and hypothyroidism, underwent bone marrow biopsy which showed a hypercellular bone marrow with >90% cellularity and 81% myeloblasts
expressing CD 34 and CD 117 markers, confirming a diagnosis of acute myeloid leukemia (AML).
Tailler et al., "A novel effect of DNA methyltransferase and histone deacetylase inhibitors : NF[kappa]B inhibition in malignant myeloblasts
," Cell Cycle, vol.
The bone marrow examination then showed 90% myeloblasts
, with immunophenotype CD45dim/117+/13dim/33+/56-/2-/15-/ 14-/11b-/99+/HLA-DR-; CD34 positivity was detected for a subpopulation of 8% of blasts.
Immature myeloid cells or extramedullary proliferation of myeloblasts
are present in MS .
Undoubtedly, blast crisis, defined as >30% myeloblasts
in the circulation [10-12], represents a critical turning point in the CML course triggering a rapid clinicobiological worsening with poor outcomes .