NMDA receptor


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Related to NMDA receptor: AMPA receptor, NMDA receptor antagonist

NMDA receptor

 (ĕn′ĕm′dē′ā′)
n.
A brain receptor activated by glutamate, which when excessively stimulated may cause cognitive defects in Alzheimer's disease.

[N-m(ethyl)-d-a(spartate), an amino acid derivative that binds selectively to the receptor.]
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References in periodicals archive ?
NMDA receptor antagonists, MK-801 and ACEA-1011, prevent the development of tonic pain following subcutaneous formalin.
"If we could find a drug that attaches itself to this site and then locks together NMDA receptor subunits, that would be huge for fighting disability from stroke and Alzheimer's and other neurodegenerative diseases."
Although glutamate and its postsynaptic NMDA receptor are normal components of nervous-system conduction, over-activation can mediate damage after SCI and other nervous-system insults (e.g., head injury, stroke, etc.).
PSD-95/SAP90 appears to mediate the role of the NMDA receptor in determining the MAC of inhalational anesthetics.
This correlated with the ability of TNF[alpha] and TNFRII agonist antibodies to stimulate increased NMDA receptor activity as observed by increased intracellular [Ca.sup.2+] levels and NMDA receptor-evoked currents.
Aptinyx announced the presentation of preclinical data on its novel NMDA receptor modulator, NYX-458.
REL-1017 is an orally administered NMDA receptor (NMDAR) antagonist indicated to be active on the NMDAR ketamine binding site.
Patent and Trademark Office (USPTO) has issued a Notice of Allowance for Patent Application 15/812,599 related to certain methods of production for AV-101, VistaGen Therapeutics' (NASDAQ: VTGN) oral NMDA receptor glycine site antagonist in Phase 2 development for major depressive disorder (MDD).