NRTI


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NRTI

abbr.
nucleoside reverse transcriptase inhibitor
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.NRTI - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs
AZT, Retrovir, ZDV, zidovudine - an antiviral drug (trade name Retrovir) used in the treatment of AIDS; adverse side effects include liver damage and suppression of the bone marrow
drug cocktail, HAART, highly active antiretroviral therapy - a combination of protease inhibitors taken with reverse transcriptase inhibitors; used in treating AIDS and HIV
3TC, lamivudine - a nucleoside reverse transcriptase inhibitor that is very effective in combination with zidovudine in treating AIDS and HIV
reverse transcriptase inhibitor - an antiviral drug that inhibits the action of reverse transcriptase in retroviruses such as HIV
Translations

NRTI

abbr nucleoside reverse transcriptase inhibitor. V. inhibitor.
References in periodicals archive ?
(NASDAQ: GILD) has presented findings from two Phase 3 trials a trial demonstrating the effectiveness of switching to Biktarvy (bictegravir 50mg/emtricitabine 200mg/tenofovir alafenamide 25mg tablets, B/F/TAF) in women, and a trial evaluating the potential for the single tablet regimen to be an effective treatment option in virologically suppressed patients with known resistance to nucleo(s)tide or non-nucleo(s)tide reverse transcriptase inhibitors (NRTIs or NNRTIs), the company said.
Both the European (5) and American (4) guidelines allow the use of boosted DRV and RAL as an NRTI sparing combination provided baseline HIV-1 VL <100,000 copies/mL and CD4 >200 cells/[mm.sup.3].
New Delhi [India], Jan 10 ( ANI ): The Union Cabinet chaired by Prime Minister Narendra Modi has approved the creation of the post of vice chancellor for India's first rail and transportation university, National Rail & Transport Institute (NRTI).
On the other hand, sex (adjusted p = 0.51), genetic background (adjusted p = 0.85), age at treatment start (adjusted p = 0.82), IL4 rs2243250, CYP3A4 and CYP2B6 SNPs, use of AZT as NRTI backbone, and events of detectable pVL following viral suppression were not significantly associated with probability to immune response on multivariate analysis.
Twelve of the 35 participants (34.3%) had received only one previous ART regimen before starting on the DRV/r-, RAL- or ETR-containing regimen (all RTV- or LPV/r-based first-line ART, including single-drug substitutions from RTV to LPV/r, a single NRTI switch, or temporary 3TC monotherapy).
However, several medications that inhibit nucleic acid synthesis have a similar effect, including the class of anti-HIV medications called nucleoside reverse transcriptase inhibitors (NRTIs).
Since HIV drug options are limited in our country and there are not enough studies that compare drug regimens in Turkish patients, we aimed to compare immunological and virological responses to three different anti-retroviral regimens by using NNRTI, PI or INI in combination with NRTI.
The observed numbers of RAMs against PI, NRTI and NNRTI are listed in Table 2.
Among EFV-based regimens, adolescents on d4T + 3TC + EFV had higher odds of reporting multiple symptoms compared with those on TDF + FTC + EFV and ABC + 3TC + EFV (in that order of decreasing odds), suggesting that the NRTI backbone may play a more important role in cART symptoms profiling than the NNRTI component.
In terms of the NRTI backbone, the combination of stavudine (d4T) and didanosine (ddI) was prescribed least frequently but was the most modified, due to nonadherence.
This would-be donor will be put on a treatment regimen that follows the 285-page Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents (1) and will be thrust into a medical world peppered with acronyms like CD4, ART, HIV RNA, HIV Ag/Ab, NRTI, NNRTI, PI, INSTI, PrEP, and P4P4P.