NRTI


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NRTI

abbr.
nucleoside reverse transcriptase inhibitor
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.NRTI - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs
AZT, Retrovir, ZDV, zidovudine - an antiviral drug (trade name Retrovir) used in the treatment of AIDS; adverse side effects include liver damage and suppression of the bone marrow
drug cocktail, HAART, highly active antiretroviral therapy - a combination of protease inhibitors taken with reverse transcriptase inhibitors; used in treating AIDS and HIV
3TC, lamivudine - a nucleoside reverse transcriptase inhibitor that is very effective in combination with zidovudine in treating AIDS and HIV
reverse transcriptase inhibitor - an antiviral drug that inhibits the action of reverse transcriptase in retroviruses such as HIV
Translations

NRTI

abbr nucleoside reverse transcriptase inhibitor. V. inhibitor.
References in periodicals archive ?
If you are not yet heavily treated and have a moderate to high CD4 T cell count, you can put together a dual NRTI combination that involves few pills, no food restrictions and twice daily
Other recent studies have shown that MRPs may also play a role in NRTI resistance by decreasing the amount of intracellular drug to levels below that necessary to inhibit HIV replication, allowing growth and evolution of drug-resistant HIV.
The Food and Drug Administration is reviewing several other antiretrovirals for once-daily labeling, including the NRTIs 3TC, abacavir, and nevirapine, and some boosted protease inhibitor combinations.
Also, all patients had been treated with most of the NRTIs available and most (35) had used at least one PI.
The researchers found that after one year of dual NRTI antiretroviral therapy, the median CD4 T cell count increased by 80 cells/[mm.
A mutation at position 151 is associated with resistance to the entire NRTI class.
As a class, NRTIs have been implicated in damage to mitochondrial DNA and may therefore play a role in the development of metabolic and morphologic abnormalities.
3%) had received only one previous ART regimen before starting on the DRV/r-, RAL- or ETR-containing regimen (all RTV- or LPV/r-based first-line ART, including single-drug substitutions from RTV to LPV/r, a single NRTI switch, or temporary 3TC monotherapy).
506 NRTI = nucleos(t)ide reverse transcriptase inhibitor; cART = combination antiretroviral therapy; AZT = zidovudine; ABC = abacavir; TDF = tenofovir d4T = stavudine; aOR = adjusted odds ratio; CI = confidence interval; Y = yes; N = no; TB = tuberculosis; ARV = antiretroviral; VL = viral load.
GSS calculation was done considering all possible combinations of: NRTI [+ or -] NRTI [+ or -] NNRTI [+ or -] PI/r [+ or -] T20 [+ or -] RAL.