CRN01941 is an oral nonpeptide somatostatin receptor subtype 2 (sst2) biased agonist designed for the treatment of neuroendocrine tumors (NETs) that originate from neuroendocrine cells
commonly found in the gut, lung, or pancreas.
Chromogranin is used to diagnose neuroendocrine tumors because it is a protein secreted by neuroendocrine cells
. Synaptophysine is a protein present in all healthy and neoplastic neuroendocrine cells
(75,76) Large cell neuroendocrine carcinoma is characterized by solid sheets, ribbons, or nests of neuroendocrine cells
with peripheral palisading and geographic necrosis.
Chromogranin A is found in the secretory granules of neuroendocrine cells
. 22 Synaptophysin is the most sensitive and chromogranin A is the most specific marker.
They found that artificially pre-activating the neuroendocrine cells
made the mice stay under general anaesthesia for longer periods of time.
SCLC is thought to develop from a particular type of lung cell, called pulmonary neuroendocrine cells
(PNECs), but until now, no one knew how to induce human embryonic stem cells to become PNECs in the lab.
In S100 immunostaining, neuroendocrine cells
and luminal epithelial cells are immunoreactive [Figure 16].
Regarding the pathogenesis of NEC of the stomach, four pathways were reported based on their precursor cell-type: common-type adenocarcinoma; carcinoid tumor; multi-potential stem cells and immature neuroendocrine cells
. Recently, many NECs of the stomach are thought to originate from common-type adenocarcinoma.
Neuroendocrine tumors are abnormal growths that begin in specialized cells, called neuroendocrine cells
, and have traits similar to nerve cells and hormone-producing cells.
 It is classified as a preneoplastic lesion because of the possibility of carcinoid development by the World Health Organization, defined as bronchial and bronchial epithelium-restricted, distributed single cells, small nodules (neuroendocrine bodies), or pulmonary neuroendocrine cells
. DIPNECH patients are often histopathologically diagnosed with pulmonary biopsies or resections and are shown to have increased chromogranin, SYNP, and CD56 in immunohistochemistry (C-13).
The researchers also found a paucity of neuroendocrine markers in pulmonary neuroendocrine cells
- a cell type thought to be the source of SCLC.
Latest developments in immunohistochemical staining techniques have led to an increased frequency of identifying few neuroendocrine cells
in adenocarcinomas in the tumor tissues.