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Related to Neutrophil collagenase: matrix metalloproteinase 8, PMNL collagenase


 (kə-lăj′ə-nās′, -nāz′, kŏl′ə-jə-)
Any of various enzymes that catalyze the hydrolysis of collagen and gelatin.


(Biochemistry) an enzyme that decomposes collagen
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.collagenase - any enzyme that catalyzes the hydrolysis of collagen and gelatin
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
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Studies on neutrophil collagenase and MMP-18 in clear cell renal cell carcinoma did not demonstrate any increase in their activity in primary tumour tissue or metastases as compared to normal tissue [3,32].
2-4) Secreted-type MMPs can be classified into 6 subgroups according to their substrate specificity and structural differences (2): (1) collagenases, including tissue collagenase (MMP1), neutrophil collagenase (MMP8), and collagenase 3 (MMP13); (2) gelatinases, such as gelatinase A (MMP2) and gelatinase B (MMP9); (3) stromelysins, including stromelysin 1 (MMP3) and stromelysin 2 (MMP-10); (4) matrilysins, such as matrilysin 1 (MMP7) and matrilysin 2 (MMP26); (5) furin-activated MMPs, including stromelysin 3 (MMP-13) and epilysin (MMP 28); and (6) other MMPs such as metalloelastase (MMP12), MMP19, enamelysin (MMP-20), MMP21, and MMP-27.
A fourth paper from Timo Sorsa, PhD, of the University of Helsinki, confirms that Periostat(R) inhibits neutrophil collagenase activity in gingival crevicular fluid samples from patients with adult periodontal disease.

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