substantia nigra

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substantia ni·gra

 (nī′grə, nĭg′rə)
A layer of large pigmented nerve cells in the midbrain that produce dopamine and whose destruction is associated with Parkinson's disease.

[New Latin : Latin substantia, substance + Latin nigra, feminine of niger, black.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

substantia nigra

(səbˈstænʃə ˈnaɪɡrə)
(Anatomy) a layer of grey matter in the brain that produces dopamine and contains pigmented nerve cells, loss of which has been associated with Parkinson's disease
[C20: from Latin, literally: dark material]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

sub•stan•ti•a ni•gra

(səbˈstæn ʃi ə ˈnaɪ grə, ˈnɪg rə)

n., pl. sub•stan•ti•ae ni•grae (sʌbˈstæn ʃiˌi ˈnaɪ gri, ˈnɪg ri) substantia ni•gras.
a deeply pigmented area of the midbrain containing dopamine-producing nerve cells.
[1880–85; < New Latin: black substance]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.substantia nigra - a layer of deeply pigmented grey matter in the midbrain; associated with the striate body; is involved in metabolic disturbances associated with Parkinson's disease and with Huntington's disease
neural structure - a structure that is part of the nervous system
mesencephalon, midbrain - the middle portion of the brain
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Drug-free evaluation of rat models of parkinsonism and nigral grafts using a new automated rotarod test.
Quantitative [(123)I]-FP-CIT pinhole SPECT imaging predicts striatal dopamine levels, but not number of nigral neurons in different mouse models of Parkinson's disease.
Cortical functioning deficits in patients with I-PD have several pathological factors such as increased levels of [11C](R)-PK11195 in cortical/ subcortical regions, susceptibility of cortical/subcortical grays due to development of proteinaceous inclusion bodies starting from brain stem bulging to cerebral cortex weakening limbic, autonomic and motor systems, constant presence of neurotoxin as nigral Glutathione transferase activity and total glutathione deficiency as a result of overutilization in response to oxidative stress, loss of corticocortical projection neurons in motor cortex, and dopamine loss.2-5
Cystatin C prevents degeneration of rat nigral dopaminergic neurons: In vitro an d in vivo studies.
(1990) Striatal and nigral neuron subpopulations in rigid Huntington's disease: implications for the functional anatomy of chorea and rigidity-akinesia.
Before 90s presynaptic mechanisms, namely all processes determining the striatal dopamine levels like production, storage, release and reuptake by the dopaminergic terminals, were more commonly accused for LID, as nigral dopaminergic cell loss is the initial and the most prominent pathological finding in PD.
Restoration of complex sensorimotor behavior and skilled forelimb use by a modified nigral cell suspension transplantation approach in the rat Parkinson model.
Kordower et al., "A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease," Annals of Neurology, vol.
Once inside the brain, MPTP is metabolized into the toxic cation 1-methyl-4-phenylpyridinium (MPP+) by the enzyme monoamine oxidase B, resulting in nigral dopaminergic neuronal death and mitochondrial damage, which can mimic the clinical and pathological features of PD [38].
Neuroinflammation plays an important role in the pathogenesis of PD and contributes to the progressive loss of nigral dopaminergic neurons [20].
Itakura, "Implantation of human amniotic epithelial cells prevents the degeneration of nigral dopamine neurons in rats with 6-hydroxydopamine lesions," Brain Research, vol.