(1) The common nature of the precursors and the facile nature of the nitrosation
reactions under acidic pH have made nitrosamines one of the common and unwelcome guests in the world of consumer goods and pharmaceuticals--the one who comes uninvited, consumes our resources, and will simply not go away.
It has been demonstrated that NO primarily causes three basic chemical reactions: nitrosylation, nitrosation
, and nitration (Figure 3) (11).
Wood et al., "Intragastric bacterial activity and nitrosation
before, during, and after treatment with omeprazole.," BMJ, vol.
of methyl 5-amino-2-hydroxybenzoate 1 by using NaN[O.sub.2] in the presence of HCl afforded the corresponding diazonium salt derivative 2.
Lactobacillus plantarum-Staphylococcus carnosus Part I: Effect of partial replacement of NaCl with KCl on the stability and the nitrosation
These account for most of the so-called indirect effects attributed to NO through oxidation, nitrosation
, and nitrate reactions referred to as oxidative, nitrosative, and nitrative stress, respectively.
The International Agency for Research on Cancer (IARC) has concluded that nitrates and nitrites are probably carcinogenic to humans under conditions favoring nitrosation
where an NO group is covalently bound to carbon, sulphur, oxygen, or nitrogen atoms in an organic molecule.
Some researchers reported that arecoline can produce nitrosamine through a nitrosation
reaction in the digestive tract of the human body.
2015), which is higher in red than in white meat, and may also facilitate endogenous nitrosation
(i.e., the production of carcinogenic A-nitroso compounds) (Cross and Sinha 2004).
"That inhibits the nitrosation
reaction," says Cross.
Secondary amines containing one aromatic nitro group: preparation, nitrosation
, sustained nitric oxide release, and the synergistic effects of released nitric oxide and an arginase inhibitor on vascular smooth muscle cell proliferation.