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The failure of paired chromosomes or sister chromatids to separate and go to different cells during meiosis.

non′dis·junc′tion·al adj.


(Genetics) the failure of paired homologous chromosomes to move to opposite poles of the cell during meiosis
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Noun1.nondisjunction - meiosis in which there is a failure of paired homologous chromosomes to separate; results in an abnormal number of chromosomes in the daughter cells
meiosis, miosis, reduction division - (genetics) cell division that produces reproductive cells in sexually reproducing organisms; the nucleus divides into four nuclei each containing half the chromosome number (leading to gametes in animals and spores in plants)
References in periodicals archive ?
The main cause of deterioration of oocyte quality is meiotic non-disjunction (20).
Aneuploidy arising from chromosomal non-disjunction (NDJ) is particularly problematic for students, since it arises in the context of meiosis, itself a challenging subject.
Subsequently non-disjunction and chromosome loss (single or more), in these cells may lead to aneuploidy and mosaicism in cleavage and blastocyst stage embryos.

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