(2) These inclusions appear in neutrophils and morphologically and cytochemically resemble Howell-Jolly bodies of normoblasts
in abnormal erythropoiesis.
A bone marrow biopsy report revealed diffuse infiltration of Langerhans cells with vesicular nuclear chromatin, irregular nuclear contours, pale cytoplasm with phagocytosed normoblasts
, and mature erythrocytes.
falciparum cases and only 20 (2.8%) cases showed normoblasts
indicating erythroid hyperplasia/ stimulation.
Peripheral smear revealed a widespread schistocytes, dacrocytes, spherocytes, normoblasts
Peripheral blood smear showed microcytic, hypochromic red blood corpuscles with immature white blood cells (WBCs; myleocytes, metamyleocytes, and bandforms) and normoblasts
Phagocytic vesicles contained red blood cells and normoblasts
, neutrophils and platelets.
Bone marrow aspiration showed hypercellularity, with 45% myeloblasts, 15% promyelocytes, 7% myelocytes, 4% metamyelocytes, 1% eosinophils, 2% neutrophils, 15% lymphocytes, and 11% normoblasts
. Wright staining of a bone marrow smear showed large (2-4 [micro]m) round-to-oval, hyaline-structured eosinophilic granules (pseudo Chediak-Higashi [PCH] granules) within 15% of the blast cells, promyelocytes, and myelocytes (Figure).
Megakaryocytes and normoblasts
are derived from a common committed progenitor cell, the CFU-GEMM (colony-forming unit, granulocytic, erythroid, myelomonocytic).
Routine full blood counts showed that, on average, the SCD patients had a normocytic, normochromic anaemia with a high white cell count, the latter usually indicative of excess normoblasts
in the peripheral blood.
These give rise to precursors that are microscopically recognisable as normoblasts
comprising the red cells series that include erythroid islands (Fig.