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 (no͞o′klē-ās′, -āz′, nyo͞o′-)
Any of several enzymes, including the endonucleases and the exonucleases, that hydrolyze bonds between nucleotides in nucleic acids.


(Biochemistry) any of a group of enzymes that hydrolyse nucleic acids to simple nucleotides


(ˈnu kliˌeɪs, -ˌeɪz, ˈnyu-)

any enzyme that catalyzes the hydrolysis of nucleic acids.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.nuclease - general term for enzymes that catalyze the hydrolysis of nucleic acid by cleaving chains of nucleotides into smaller units
endonuclease - a nuclease that cleaves nucleic acids at interior bonds and so produces fragments of various sizes
exonuclease - a nuclease that releases one nucleotide at a time (serially) beginning at one of a nucleic acid
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
References in periodicals archive ?
We believe Sangamos zinc finger nucleases provide the optimal gene editing platform, and we look forward to working with Sangamo to accelerate our efforts to develop next-generation autologous cell therapies, as well as allogeneic treatments that can be accessed more conveniently in the hospital setting for people living with cancer.
0 Cms1 genome editing nucleases tools to accelerate crop performance improvements.
Feldan Therapeutics can use its platform to deliver CRISPR nucleases and edit the genome of human NK cells.
Fetal calf serum contains heat-stable nucleases that degrade neutrophil extracellular traps.
Zinc finger nucleases (ZFNs) and Transcription activator like effectors nucleases (TALENs).
These sequence-specific genome editing nucleases bring out DSB (double strand break) at specific desired location in the genome.
Zinc finger nucleases (ZFNs) are a powerful technology for genome engineering that allow researchers to induce subtle mutations.
There are four major classes of gene editing technologies, including meganuclease and their derivatives, Zinc Finger Nucleases (ZFNs), Transcription Activator-Like Effector Nucleases (TALENs), and Clustered Regularly Interspaced Short Palindromic (CRISPR)-associated nuclease Cas9.
For this reason, only ultrapure water free of nucleases should be used for all buffer dilutions and system-running buffers.
The researchers used specially designed enzymes, called zinc finger nucleases and transcription activator-like effector nucleases, to create a double strand break in the DNA and bring about the repair of the gene.
Each participant had their immune cells harvested from the blood, then researchers applied zinc-finger nucleases to edit genomes.