NRTI

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Related to Nucleoside reverse transcriptase inhibitors: Protease inhibitors

NRTI

abbr.
nucleoside reverse transcriptase inhibitor
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.NRTI - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs
AZT, Retrovir, ZDV, zidovudine - an antiviral drug (trade name Retrovir) used in the treatment of AIDS; adverse side effects include liver damage and suppression of the bone marrow
drug cocktail, HAART, highly active antiretroviral therapy - a combination of protease inhibitors taken with reverse transcriptase inhibitors; used in treating AIDS and HIV
3TC, lamivudine - a nucleoside reverse transcriptase inhibitor that is very effective in combination with zidovudine in treating AIDS and HIV
reverse transcriptase inhibitor - an antiviral drug that inhibits the action of reverse transcriptase in retroviruses such as HIV
Translations

NRTI

abbr nucleoside reverse transcriptase inhibitor. V. inhibitor.
References in periodicals archive ?
Nucleoside reverse transcriptase inhibitors (NRTIs) have been used to boost antiviral efficacy when constructing antiretroviral (ARV) regimens for patients with virologic failure.
There are no clinically significant pharmacokinetic interactions between nucleoside reverse transcriptase inhibitors (NRTIs) and rifampicin-based TB treatment.
Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients The SMART/INSIGHT and DAD Study Groups AIDS, 2008, 22, F17-F24
The survey, which looked at specimens from 3,130 newly diagnosed, drug-naive individuals, found that 4% of infections had mutations conferring resistance to nucleoside reverse transcriptase inhibitors, 7% to nonnucleoside reverse transcriptase inhibitors, and 2% to protease inhibitors.
After 24 weeks, the combination of Invirase, Agenerase, and Norvir plus nucleoside reverse transcriptase inhibitors (NRTIs or "nukes") decreased viral load and increased T cell count.
These results show that the investigational, long acting, injectable formulations of cabotegravir (ViiV Healthcare) and rilpivirine (Janssen) were comparable in maintaining viral suppression rates to a three drug oral regimen of investigational cabotegravir and two nucleoside reverse transcriptase inhibitors (NRTIs).
The guidelines advocate initial treatment regimens that consist of two nucleoside reverse transcriptase inhibitors (NR-TIs) plus either the non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz or a ritonavir-boosted protease inhibitor (PI/r).
Reverset appears to be an excellent addition to our armamentarium of nucleoside reverse transcriptase inhibitors.
If approved by regulatory authorities, the two drug fixed-dose combination therapy being developed by ViiV Healthcare and Janssen could offer people living with HIV an option to switch from a standard three drug therapy to a two drug nucleoside reverse transcriptase inhibitors (NRTI)-sparing combination, once a stable suppressed viral load has been achieved.
However, while we know resistance can slow this virus down--we all know resistant virus can win; look at what happened in the era of treating with just nucleoside reverse transcriptase inhibitors (NRTIs) and the ongoing deaths from uncontrolled HIV.

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