Pneumolysin generally intervene host cell by binding to membrane cholesterol and then oligomerize
to form macromolecular pores in the host cell membrane which leads to cell death .
Permeabilization of the mitochondrial membrane relies on the B-cell lymphoma 2 (Bcl-2) protein family, where pro-apoptotic Bcl-2-associated X (Bax) or Bcl-2 homologous killer (Bak) proteins oligomerize
to form pores on the outer mitochondrial membrane (OMM; Tait and Green 2010).
Overexpression of SAMT14 and MARCH11 in hEk 293T cells indicates that MARCH11 can interact with all four SAMT proteins and that each the SAMT proteins can oligomerize
with themselves and each other.
After binding to membranes, toxin monomers diffuse laterally in the bilayer and oligomerize
to form homotypic aggregates that represent very large transmembrane pores.
Studies by Si and others in the past few years have hinted that CPEB's tendency to oligomerize
is not merely incidental, but is indeed essential to its ability to stabilize longer-term memory.
One report suggested that proANP and proBNP may oligomerize
through a leucine zipperlike motif in the midregion (42).
In recent years, a paradigm shift has occurred regarding how cytokine receptors oligomerize
and deliver signals.
It can oligomerize
following its inclusion into a lipid membrane creating ion channels.
In contrast, itaconic acid does not oligomerize
with itself but instead is believed to copolymerize readily with other monomers (i.
Connexins form hemichannels when six subunits oligomerize
to form a hexameric ring, which initially adopts a closed configuration.