In prokaryotes many TFs oligomerize
and the complex recognizes a sequence of 6-8 nucleotides and these oligomers interact on DNA using weak interactions to effectively increase the size of the target site recognized to 12-16 nucleotides.
Taken together, the results suggest that the Nesprin-2-SMC domain has the potential to oligomerize
. We then asked whether this interaction is specific to this Nesprin-2 domain and tested whether GSTNesprin-2-SMC could interact with other spectrin repeats of Nesprin-2.
Inadequate cleavage of APP may lead to formation of abnormally long peptides, such as A[beta]1-42 fragments, which are more likely to oligomerize
and form plaques, compared with shorter fragments such as A[beta]1-40 .
To date, 15 different members have been identified, which are classified according to their biochemical structure into three groups: (a) prototype galectins, including galectin- (Gal-) 1, -2, -5, -7,10, -11, -13, -14, and -15, display one carbohydrate-recognition domain (CRD) and can dimerize; (b) tandem-repeat galectins, including Gal-4, -6, -8, -9, and -12, exhibit two CRDs associated with a linker peptide; and (c) the unique chimera-type Gal-3 contains one CRD and an additional nonlectin domain and can oligomerize
In order to be converted into their active forms and be secreted, the cytokines require subsequent caspase cleavage, which determine NLRP3 to oligomerize
in the presence of an adaptor molecule--ASC (apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain), and finally resulting in secretion of proinflammatory cytokines.
Pneumolysin generally intervene host cell by binding to membrane cholesterol and then oligomerize
to form macromolecular pores in the host cell membrane which leads to cell death .
Velours, "In the absence of the first membrane-spanning segment of subunit 4(b), the yeast ATP synthase is functional but does not dimerize or oligomerize
," The Journal of Biological Chemistry, vol.
Dewson, "Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize
during apoptosis," Cell Death and Differentiation, vol.
Native gel showed that GsiAcould oligomerize
in gel filtration buffer.
Permeabilization of the mitochondrial membrane relies on the B-cell lymphoma 2 (Bcl-2) protein family, where pro-apoptotic Bcl-2-associated X (Bax) or Bcl-2 homologous killer (Bak) proteins oligomerize
to form pores on the outer mitochondrial membrane (OMM; Tait and Green 2010).
In the pore hypothesis, amyloid species can interact with the membrane surface and oligomerize
to form localized pores or channels that cause an uncontrolled, nonphysiological flux of ions across the membrane [9, 10, 14].
Overexpression of SAMT14 and MARCH11 in hEk 293T cells indicates that MARCH11 can interact with all four SAMT proteins and that each the SAMT proteins can oligomerize
with themselves and each other.