The company offers services for DNA, RNA and other oligonucleotides
based therapeutics from milligram scale at pre-clinical stage to 1000kg + post commercial launch.
Major factors contributing to the growth of the global oligonucleotide
synthesis market include increasing R&D expenses in the pharmaceutical and biotechnology companies, rising demand for synthesized oligonucleotides
due to the growing field of molecular diagnostics, increasing government investments to develop genomic technologies, rising venture capital investments, and increasing demand for synthetic genes.
This contract is for the supply, delivery and installation of an oligonucleotide
synthesizer, designed to be integrated into the synthesis and purification of oligonucleotides
platform of bioimaging Institute of the University of Bordeaux.
This alliance with Girindus allows us to move the development and supply of CRN-based oligonucleotides
to a team with exceptional experience and capability thus allowing us to focus on bringing novel therapeutics to patients in need.
Handbook of analysis of oligonucleotides
and related products.
The Clarity OTX protocol uses a propriety mixture of chaotropes, detergents, and other dispersants to disrupt intermolecular interactions that are common for oligonucleotides
in biological matrices.
Editors Moretti and Rizzo (no affiliations listed) have collected research in the field on the use of oligonucleotides
for detecting complementary DNA and RNA such as in DNA microarrays and the synthesis of artificial genes.
Methods: Nuclear extracts from hematopoietic and non-hematopoietic cells are incubated with labeled double stranded oligonucleotides
from 50-200 bp in length in EMSA binding buffer.
We have developed a specific chemical process that generates a fluorescent product on annealing of 2 oligonucleotides
to each other.
The 2 oligonucleotides
harbor adaptors (in lower case) corresponding to universal forward and reverse oligonucleotides
that can be used for sequencing after amplification.
Building on our 17 year history in oligonucleotide
manufacture and analysis, Dalton can now use its expertise in synthesis and manufacturing of antisense oligonucleotides
and their analogs to produce cGMP grade oligonucleotides
as required for human clinical testing.
TriLink offers small-scale oligonucleotides
for the discovery and pre-clinical stages of drug development to customers exploring a wide variety of DNA or RNA based therapies.