However, the most popular therapy for advanced histiocytic sarcoma appears to be cyclophosphamide, hydroxydaunorubicin, oncovin
, and prednisone.
After Pre-Chemotherapy Workup, Multidrug Chemotherapy (Etoposide, Methotrexate, Actinomycin - D, Cyclo-phosphamide, Oncovin
/ Vincristine) was started and the patient was regularly monitored by CBCs, LFTs, RFTs and Serum [beta] HCG.
Abbreviations HL--Hodgkin lymphoma NHL--non-Hodgkin lymphoma DLBCL--diffuse large B-cell lymphoma R-CHOP--rituximab - cyclophosphamide, hydroxydaunomycin, oncovin
, prednisolone NK--natural killer NOS--not otherwise specified NGC--non germinal center 80--85% of DLBCL.
He was planned for standard treatment of rituximab-cyclophosphamide, hydroxydaunorubicin, Oncovin
, and prednisone (R-CHOP), but the patient developed upper gastrointestinal bleed and succumbed to death before starting the chemotherapy.
He received orchiectomy, prophylactic intrathecal injection, and 6 cycles of chemotherapy with rituximab-etoposide, prednisone, oncovin
(vincristine), cyclophosphamide, and hydroxydaunorubicin (doxorubicin) (RDA- EPOCH).
The patient was submitted to chemotherapy with six cycles of R-CHOP (rituximab + cyclophosphamide, hydroxydaunorubicin, oncovin
, and prednisone), after surgery.
The main complaints were pain in both ears, diplopia, and restriction of inward movement of the left eye after the CHOP (Cyclophosphamide, Hydroxydaunorubicin, Oncovin
, and Prednisone) treatment.
Following the diagnosis of THRLBCL, the patient was treated with R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) given the lack of data to support use of a more aggressive regimen such as DA-R-EPOCH (dose-adjusted Rituximab, Etoposide, Prednisone, Vincristine (Oncovin
), Cyclophosphamide, and Doxorubicin).
Patient was administered 6 cycles of R-CHOP (Rituximab 375 mg/[m.sup.2], Cyclophosphamide 750 mg/[m.sup.2], Doxorubicin 50 mg/[m.sup.2], Oncovin
1.4 mg/[m.sup.2], with dose of prednisolone modified to 80 mg because of her diabetes) following which her lesion resolved completely.
marneffei Antifungal treatment Amphotericin B (2 (duration, mo) weeks) and voriconazole (>5) Other opportunistic Herpes zoster infections at right occiput Clinical outcome Responded to antifungal treatment * mAb, monoclonal antibody; JAK, Janus kinase; IV, intravenous; CHOP, cyclophosphamide, hydroxydaunorubicin, oncovin
, and prednisolone; MRCNS, methicillin-resistant coagulase-negative Staphylococcus; HSV, herpes simplex virus; PJP, Pneumocystis jiroveci pneumonia; MODS, multiple organ dysfunction syndrome.