(redirected from Opioid receptors)
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Related to Opioid receptors: Opioid Analgesics


Any of various compounds that bind to specific receptors in the central nervous system and have analgesic and narcotic effects, including naturally occurring substances such as morphine; synthetic and semisynthetic drugs such as methadone and oxycodone; and certain peptides produced by the body, such as endorphins. Also called opiate.

o′pi·oid′ adj.


a. any of a group of substances that resemble morphine in their physiological or pharmacological effects, esp in their pain-relieving properties
b. (modifier) of or relating to such substances: opioid receptor; opioid analgesic.


(ˈoʊ piˌɔɪd)

1. any opiumlike substance, as the endorphins produced by the body or the synthetic compound methadone.
2. pertaining to such a substance.


adj & n opioide m
References in periodicals archive ?
Cebranopadol is a first-in-class drug candidate due in large part to its unique ability to bind with high affinity to not only classical opioid receptors, but also the nociceptin/ orphanin FQ peptide, or NOP, receptors which may offer improved management of some pain states with decreased side effects.
But now, neuroscientists found a way to activate opioid receptors with light.
ADL5945, Adolor's new therapy for the treatment of opioid-induced bowel dysfunction (OBD) with a focus on the primary symptom, opioid induced constipation (OIC), is a potent, orally available antagonist of peripheral mu opioid receptors in the GI tract that has the potential to provide substantial relief to this patient population and become a 'best in class' drug," said Andrew I.
Scientists know of four distinct types of opioid receptors, but until now the structure of the 'salvia receptor', and the details about how salvinorin A and other drugs interact with it, was a mystery.
The new work, by Ruth Gross-Isserof of the Weizmann Institute of Science in Rehovot, Israel, and Anat Biegon of the New York University School of Medicine in New York City, is the first to look at opioid receptors in suicide victims' brains.
In the Phase III clinical studies, MOVANTIK was administered as a once-daily tablet and is designed to block the binding of opioids to the opioid receptors in the gastrointestinal (GI) tract without impacting the opioid receptors in the brain.
For example, both morphine and sucrose infusions increase pain thresholds and reduce distress cries in 10-day-old rats; naltrexone, a substance that blocks opioid receptors and thus interferes with morphine's effects, similarly suppresses sucrose's ability to soothe.
Narcotic analgesics decrease pain by activating opioid receptors, which are located on nerves that transmit painful sensations.
Hershey Medical Center in Hershey, if a compound that blocks opioid receptors is injected prior to examination of the brain--thus making the body's opioids ineffective-- there is a greater-than-normal proliferation of brain cells.
Naloxegol is a once-daily tablet designed to block the binding of opioids to the opioid receptors in the gastrointestinal (GI) tract without impacting the opioid receptors in the brain.
Naltrexone, a drug that blocks opioid receptors in the brain, is used primarily to treat alcohol dependence, but is effective only in around 78 percent of people, reports New Scientist.
a biopharmaceutical company focused on developing and commercializing new chemical entities designed to alleviate pain by selectively targeting kappa opioid receptors, announced today that it has filed a registration statement on Form S-1 with the U.