opsonin

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op·so·nin

 (ŏp′sə-nĭn)
n.
A substance, such as an antibody or complement protein, that binds to a bacterium or other pathogen and causes it to become more susceptible to the action of phagocytes.

[Latin opsōnāre, to buy provisions (from Greek opsōnein, from opson, condiment, delicacy; see epi in Indo-European roots) + -in.]

opsonin

(ˈɒpsənɪn)
n
(Biochemistry) a constituent of blood serum that renders invading bacteria more susceptible to ingestion by phagocytes in the serum
[C20: from Greek opsōnion victuals]
opsonic adj

op•so•nin

(ˈɒp sə nɪn)

n.
any of several constituents of blood serum, as an antibody or complement, that make invading microorganisms more susceptible to destruction by phagocytes.
[1900–05; < Latin opsōn(ium) victuals]
op•son•ic (ɒpˈsɒn ɪk) adj.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.opsonin - an antibody in blood serum that attaches to invading microorganisms and other antigens to make them more susceptible to the action of phagocytes
blood serum, serum - an amber, watery fluid, rich in proteins, that separates out when blood coagulates
antibody - any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response
Translations
opsonina

op·so·nin

n. opsonina, anticuerpo que al combinarse con un antígeno hace que éste sea más suceptible a los fagocitos.
References in periodicals archive ?
Some products of complement activation are chemotactic to inflammatory cells (C5a), act as opsonins (C3b), and can increase vascular permeability (C3a and C5a).
However, covalent binding method has been found to rule over the adsorption method since in vivo opsonins may compete with the adsorbed molecules onto NP surface.
It is well known that following intravenous injection of radiolabeled magnetic nanoparticles in the bloodstream, plasma proteins, namely, opsonins, are adsorbed onto the surface of the nanoparticles [46].
The presence of polyethylene glycol (PEG) on the surface of liposomes provides a steric barrier against opsonins that reduces the uptake of liposomes by the MPS cells [13, 14] and thus allows their uptake by other cells.
It is known that natural Abs to GlcNAc[beta]1-6 polysaccharide (a broadly distributed antigen among human pathogens) are common in humans but these Abs do not protect against infection due to the lack of deposition of complement opsonins [43].
A major drawback of these nanoparticles is their relative instability in biological fluids due to the interaction with biomolecules such as opsonins that further promote their uptake by mononuclear phagocyte system (MPS) cells [3,9] if used in in vivo experiments.
C3b is one of the primary complement opsonins and has been shown to tag synapses targeted for elimination [15, 19, 23].
Second, antibodies can activate the classical complement cascade through binding to Fc-fragment which triggers the production of potent anaphylatoxins, chemoattractants, opsonins, and cell-damaging factors.
Many acute-phase proteins such as CRP and SAA, bind to microbial cell walls and they may act as opsonins and fix complement.
This bacterium inhibits the chemotaxis of neutrophils, suppresses the opsonins (both complement and immunoglobulin) and phagocytes, could rapidly react to abrupt changes in ROS (Lavoie et al., 2011; Laarman et al., 2012).
The activation proceeds as an enzyme cascade with proteins acting as cofactors for each other thus generating opsonins for enhanced cellular recognition (C3b), anaphylatoxins that drive local inflammation (C3a and C5a), and terminally the membrane-attack complex (C5b-9) that mediates cell lysis.
Poloxamers are also reported to sterically stabilize the nanoparticles and reduce the adsorption plasma proteins or opsonins on the surface of nanoparticles by providing hydrophilic property to the surface of nanoparticles and thus can prevent the clearance of drug containing SLN from circulation [15].