bioavailability

(redirected from Oral bioavailability)
Also found in: Medical, Encyclopedia.

bi·o·a·vail·a·bil·i·ty

 (bī′ō-ə-vā′lə-bĭl′ĭ-tē)
n.
The degree to which or rate at which a drug or other substance is absorbed or becomes available at the site of physiological activity after administration.

bi′o·a·vail′a·ble (-lə-bəl) adj.

bioavailability

(ˌbaɪəʊəˌveɪləˈbɪlɪtɪ)
n
(Medicine) the extent to which a drug or other substance is taken up by a specific tissue or organ after administration; the proportion of the dose of a drug that reaches the systemic circulation intact after administration by a route other than intravenous. Also called: systemic availability
ˌbioaˈvailable adj

bi•o•a•vail•a•bil•i•ty

(ˌbaɪ oʊ əˌveɪ ləˈbɪl ɪ ti)

n.
the extent to which a substance can be used by the body.
[1965–70]
bi`o•a•vail′a•ble, adj.
References in periodicals archive ?
SNAC, which is based on Emispherea[euro](tm)s Eligen Technology, facilitates transport of these and other hormones with low oral bioavailability across biological membranes, such as those of the gastrointestinal tract.
This Phase I clinical trial is reportedly a randomized, open-label, four-way cross-over study designed to determine the oral bioavailability of multiple formulations of omecamtiv mecarbil in 60 healthy subjects.
The drug was well-tolerated at all doses in the study, displayed good oral bioavailability with rapid absorption, and its PK profile supports dosing on a once-daily (QD) or twice-daily (BID) schedule, Nektar said.
NKTR-181 also displayed good oral bioavailability with rapid absorption, and its plasma half-life supports its potential to be dosed on a once-daily (QD) or twice-daily (BID) schedule.