ortholog


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Related to ortholog: paralog

or·tho·log

or or·tho·logue  (ôr′thə-lôg′, -lŏg′)
n.
A homologous gene that is related to those in different organisms by descent from the DNA of a common ancestor and that may or may not have the same function.

[Back-formation from orthologous : ortho- + (homo)logous.]

or·thol′o·gous (-thŏl′ə-gəs) adj.
References in periodicals archive ?
v] channel potency and subtype selectivity, and determine species ortholog activity.
Although humans lack a direct ortholog of Sult3a1, the human sulfotransferase with the closest amino acid similarity is a phenol sulfotransferase called SULT1A1 (Brix et al.
The rat and human CYP2D isoforms share a high sequence identity (>70%), and CYP2D1 is the rat ortholog of human CYP2D6 (Venhorst et al.
frugiperda ortholog of this protein, encoding 11 CS-[alpha][beta]-motifs (Girard et al.
Further specificity analysis reveals a subset of functional antibody clones capable of recognizing the rodent ortholog of the target, enabling in vivo pharmacology studies.
This represents a significant achievement in relating human and mouse genetics because the human ortholog of this gene (MPDZ) has been shown to potentially contribute to alcoholism risk (Milner and Buck 2010).
The tree suggests that the Sn-AIF-I gene is an ortholog of an AIF gene sequence already described for the purple sea urchin (Nair et al.
Identification, genomic organization, chromosomal mapping and mutation analysis of the human INV gene, the ortholog of a murine gene implicated in left-right axis development and biliary atresia.
The region on mouse chromosome 4 shows only 50% homology with the human 9p21 region, however, and no ANRIL ortholog exists in the mouse (85), thus raising additional questions about the discrepancies and commonalities of the different 9p21 studies.
The methyltransferase protein also was found to have an ortholog, or similar counterpart, in human DNA.
A single-nucleotide polymorphism in the human ortholog of Hangover (ZNF699) recently was correlated with alcohol dependence in Irish populations (Riley et al.
Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice.