Callinectes sapidus eIF4E1 is the ortholog
of human eIF4E1 and has the eight conserved tryptophans, including those equivalent to W56 and W102 in H.
This is because SaCas9 is a compact Cas9 ortholog
suitable for viral delivery or biomedical applications.
We annotated putative coding sequences using GeneMark (7) and performed ortholog
identification, based on the prototypal human reference genome CT_020221853, using BLAST+ (8) with a 1 x [10.sup.-10] E-value threshold and confirmed by a synteny conservation check.
Identification of potential mammalian slincR orthologs
. The slncky Evolution Browser contains alignments and evolutionary metrics of lncRNAs conserved in the mouse (mm10, GRCm38) and human (hg38, GRCh38) genomes and was used to identify the potential human ortholog
of slincR (Chen et al.
This strain has a deletion from 1 kb upstream and the first three exons of the ador-1 gene, and was outcrossed 6 times; ador-1 gene encodes an ortholog
of human adenosine receptor (9).
(20) However, sequence homology searches were unable to identify a mammalian ortholog
On the other hand, defects in the gene mauve (mv) in Drosophila, which is ortholog
of LYST, affect the autophagosome function (40).
In contrast to c-Fos, Egr-1, and NPY-R, an ortholog
for the immediate-early gene Arc has not been detected in zebrafish.
The human ortholog
of hangover is ZNF699, and human studies have identified polymorphisms in this gene associated with alcohol dependence [271, 272].
Bovine caspase13 is presumed to represent the ortholog
of human caspase4 .
Tick subolesin (SUB), the ortholog
of insect and vertebrate akirins (AKR), was discovered as a tick protective antigen in Ixodes scapularis .