v] channel potency and subtype selectivity, and determine species ortholog
Although humans lack a direct ortholog
of Sult3a1, the human sulfotransferase with the closest amino acid similarity is a phenol sulfotransferase called SULT1A1 (Brix et al.
The rat and human CYP2D isoforms share a high sequence identity (>70%), and CYP2D1 is the rat ortholog
of human CYP2D6 (Venhorst et al.
of this protein, encoding 11 CS-[alpha][beta]-motifs (Girard et al.
Further specificity analysis reveals a subset of functional antibody clones capable of recognizing the rodent ortholog
of the target, enabling in vivo pharmacology studies.
This represents a significant achievement in relating human and mouse genetics because the human ortholog
of this gene (MPDZ) has been shown to potentially contribute to alcoholism risk (Milner and Buck 2010).
The tree suggests that the Sn-AIF-I gene is an ortholog
of an AIF gene sequence already described for the purple sea urchin (Nair et al.
Identification, genomic organization, chromosomal mapping and mutation analysis of the human INV gene, the ortholog
of a murine gene implicated in left-right axis development and biliary atresia.
The region on mouse chromosome 4 shows only 50% homology with the human 9p21 region, however, and no ANRIL ortholog
exists in the mouse (85), thus raising additional questions about the discrepancies and commonalities of the different 9p21 studies.
The methyltransferase protein also was found to have an ortholog
, or similar counterpart, in human DNA.
A single-nucleotide polymorphism in the human ortholog
of Hangover (ZNF699) recently was correlated with alcohol dependence in Irish populations (Riley et al.
Overexpression of 12/15-lipoxygenase, an ortholog
of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice.