Callinectes sapidus eIF4E1 is the
ortholog of human eIF4E1 and has the eight conserved tryptophans, including those equivalent to W56 and W102 in H.
This is because SaCas9 is a compact Cas9
ortholog suitable for viral delivery or biomedical applications.
We annotated putative coding sequences using GeneMark (7) and performed
ortholog identification, based on the prototypal human reference genome CT_020221853, using BLAST+ (8) with a 1 x [10.sup.-10] E-value threshold and confirmed by a synteny conservation check.
Identification of potential mammalian slincR
orthologs. The slncky Evolution Browser contains alignments and evolutionary metrics of lncRNAs conserved in the mouse (mm10, GRCm38) and human (hg38, GRCh38) genomes and was used to identify the potential human
ortholog of slincR (Chen et al.
This strain has a deletion from 1 kb upstream and the first three exons of the ador-1 gene, and was outcrossed 6 times; ador-1 gene encodes an
ortholog of human adenosine receptor (9).
(20) However, sequence homology searches were unable to identify a mammalian
ortholog of Rpn4.
On the other hand, defects in the gene mauve (mv) in Drosophila, which is
ortholog of LYST, affect the autophagosome function (40).
In contrast to c-Fos, Egr-1, and NPY-R, an
ortholog for the immediate-early gene Arc has not been detected in zebrafish.
The human
ortholog of hangover is ZNF699, and human studies have identified polymorphisms in this gene associated with alcohol dependence [271, 272].
Bovine caspase13 is presumed to represent the
ortholog of human caspase4 [28].
Tick subolesin (SUB), the
ortholog of insect and vertebrate akirins (AKR), was discovered as a tick protective antigen in Ixodes scapularis [16].