Oxamate


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Ox`am´ate


n.1.(Chem.) A salt of oxamic acid.
Webster's Revised Unabridged Dictionary, published 1913 by G. & C. Merriam Co.
References in periodicals archive ?
The pikas of experimental group were injected with 1 mL of 1 mol/L N-isopropyl oxamate, a specific LDH-C4 inhibitor, in biceps femoris muscle of hind legs, each leg with 500 uL.
Moreover, we can induce F9 cell differentiation towards an extraembryonic lineage using dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, or oxamate, a lactate dehydrogenase A (LDHA) inhibitor, which would indicate that the metabolic status of a cell determines whether it will remain pluripotent or if it will differentiate towards a specific lineage.
Inhibition of pyruvate transport to the mitochondria or pentose phosphate pathway does not affect the activity of RdCVF, while, oxamate, a lactate dehydrogenase inhibitor, abolishes RdCVF effects on cones.
In their study, the oxidation of lactate and pyruvate molecules by muscle mitochondria was blocked by the MCT protein inhibitor (alpha-cyano-4-hydroxycinnamic acid), while the inhibitor of the LDH enzyme (oxamate) blocked the oxidation of the lactate molecule but not the pyruvate molecule.
Wai-Nang Lee, of the Los Angeles Biomedical Research Institute, and colleagues also discovered an enzyme inhibitor called oxamate, which is known to reduce LDHA activity, functioned in a similar manner and also disrupted the metabolic system of pancreatic cancer cells.
The researchers also found an enzyme inhibitor, oxamate - known to reduce LDHA activity - operated in the same manner: It also disrupted the metabolic system of pancreatic cancer cells.
The researchers also found an enzyme inhibitor oxamate, which is known to reduce LDHA activity, operated in the same manner.
Researchers also found that an enzyme inhibitor, oxamate, which is known to reduce LDHA activity, also disrupted the pancreatic cancer cells metabolic system.
The researchers also found an enzyme inhibitor, oxamate, which is known to reduce LDHA activity, operated in the same manner: It also disrupted the pancreatic cancer cells metabolic system.
In the second experiment, strip steaks were cut in half and one side was injected with oxamate, an LDH inhibitor.
However, 2-n-decylquinazolin-4-yl-amine (DQA), a potent inhibitor of complex I, and oxamate, an inhibitor of LD, did not significantly influence PDHC activity (Fig.