First group served as a normal control (-ve) group, fed on standard diet only, while the other 5 groups rats were fed on standard diet containing 2% potassium oxonate for six weeks before the start of the experiment to induce hyperuricemia.
The objective of the study is to evaluate the effect of diet supplemented with soybeans, white beans alone or combined with fenugreek on experimental hyperuricemia induced by potassium oxonate in rats.
Potassium oxonate was purchased from El-Nil Company for inducing hyperuricemia.
Furthermore, luteolin which is a potent inhibitor of XO in vitro does not produce any observable hypouricemic effects after acute oral treatment in potassium oxonate
treated rats (Sarawek et al.
CDHP increases the activity of 5FU by inhibiting dihydropyrimidine dehydrogenase, the rate-limiting enzyme for the catabolism of 5-FU, while potassium oxonate
decreases the gastrointestinal toxicity of 5-FU by preventing phosphorylation in the gastrointestinal tract.
We then examined if these two compounds were effective in reducing serum uric acid levels in a hyperuricemic mouse model induced by potassium oxonate.
As continue to research on this herbal, in this study, we have isolated other two steroidal glycosides named riparoside B and timosaponin J, we then examined them in reducing serum uric acid levels in mice model of hyperuricemia induced by potassium oxonate.
The uricase inhibitor potassium oxonate was used to induce hyperuricemia in mice according to previous reports (Li et al.
2006) demonstrated that cassia oil significantly reduced serum and hepatic urate levels in the hyperuricemia mice caused by oxonate.
Potassium oxonate (PO) is an uricase inhibitor (Stavric et al.
Effects of cinnamaldehyde and allopurinol on serum urate levels in hyperuricemic mice induced by potassium oxonate
Smolen, JM, Stone, AT, "Divalent Metal Ion-Catalyzed Hydrolysis of Phosphorothionate Ester Pesticides and Their Corresponding Oxonates