In one such model, rats were treated with oxonic acid (a uricase inhibitor) to approximate the human situation, in which our evolutionary loss of uricase resulted in increases in serum urate levels.
In rats that have been partially nephrectomized, administration of the uricase inhibitor oxonic acid results in increased proteinuria and glomerulosclerosis, whereas urate lowering using allopurinol reverses this effect.
24) Indeed, rats treated with oxonic
acid (a uricase inhibitor) simultaneously experience a rise in serum urate and a fall in serum nitric oxide, an effect that can be reversed with the lowering of uric acid by allopurinol (a xanthine oxidase inhibitor).
The investigators then treated the animals with oxonic
acid, a uricase inhibitor, and the rats' blood pressure returned to normal or higher than normal levels.
16) Serum urate also has been implicated in hypertension by a series of studies in rats treated with the uricase inhibitor oxonic