oxidative phosphorylation

(redirected from Oxphos)
Also found in: Thesaurus, Medical, Acronyms, Encyclopedia.

oxidative phosphorylation

n.
The process in cell metabolism by which respiratory enzymes in the mitochondria synthesize ATP from ADP and inorganic phosphate during the oxidation of NADH by molecular oxygen.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

oxidative phosphorylation

n
(Biochemistry) the process by which the energy liberated by oxidation of metabolites is used to synthesize the energy-rich molecule ATP
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

ox′idative phosphoryla′tion



n.
the aerobic synthesis, coupled to electron transport, of ATP from phosphate and ADP.
[1950–55]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.oxidative phosphorylation - an enzymatic process in cell metabolism that synthesizes ATP from ADP
citric acid cycle, Krebs citric acid cycle, Krebs cycle, tricarboxylic acid cycle - in all plants and animals: a series of enzymatic reactions in mitochondria involving oxidative metabolism of acetyl compounds to produce high-energy phosphate compounds that are the source of cellular energy
biological process, organic process - a process occurring in living organisms
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
OxPhos capability is linked to the structural integrity of mitochondrial cristae (Frey et al, 2000; Putignani et al, 2008; Paumard et al, 2008).
As aforementioned, IGF2BP2 mediates the growth of gliomaspheres formed by glioblastoma stem cells by controlling OXPHOS through dozens of genes involved in mitochondria activity [17].
This in turn drives the catabolic processes, such as activating PGC1[alpha] and mitochondrial OXPHOS which are crucial in regulating DC activation [57, 58].
have put forward that resveratrol improves mitochondrial morphology, dynamics, and OXPHOS via a decrease in mitofusin 2 (MFN2) and an increase in optic atrophy-l protein (OPAl), I-NDUFB8, II-SDNB, III-UQCRC2, VATPase complexes, and voltage-dependent anion channel 1 (VDACl)/porin [103].
The aim of the present study was to elucidate changes in aerobic mitochondrial energy metabolism in GC and gastritis and evaluate the pathophysiologic significance of HP infection on expression of subunits of the OXPHOS complexes.
Moreover, the overexpression of miR-122 was shown to switch HCC cell metabolism from aerobic glycolysis to OXPHOS [167].
Using trans-mitochondrial hybrid cells, mtSNP A8701G was shown to cause abnormal results in impaired mitochondrial pH and intracellular calcium dynamics and is suspected to be associated with the pathogenesis of some diseases.[sup][25] Complex V or ATP synthase, the final enzyme of the OXPHOS system, enables protons to flow back to the matrix and uses the released energy to synthesize ATP.
The dose-response relationship tested in separate experiments is shown in Figure 7 for state S3 (OXPHOS), where glutamate, malate, pyruvate, succinate, and ADP were present in the medium, and for state S3u (ETS), where mitochondria where uncoupled by FCCP.
Cancer cells actually use a combination of both glycolysis and mitochondrial respiration to produce energy, and they may vary in regards to the preferential use of these pathways, being in some cases either more glycolytic/less oxidative or less glycolytic/more oxidative, depending on the prevalent normoxic or hypoxic environmental conditions and their capacities to express adequate levels of oncogenes and tumor suppressor gene products for cell growth [136-139], or when either glycolysis or OxPhos is inhibited, in whose case there can be partial compensation by the other metabolic pathway [17].
They are the powerhouse of the cell, providing the cell with adenosine triphosphate (ATP) generated by oxidative phosphorylation (OXPHOS).
Large functional range of steady-Mate levels of nuclear and mitochondrial transcripts coding for the subunits of the human mitochondrial OXPHOS system.
The enzymes of the mitochondrial energy-generating system (MEGS) [2] are localized in the mitochondrial matrix space [pyruvate dehydrogenase complex (PDHc) and tricarboxylic acid (TCA) or Krebs cycle] and in the inner mitochondrial membrane [oxidative phosphorylation (OXPHOS) complex] (1).