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"Valentis has what could be the best PEGylation technology platform available today," stated Dr.
Bein, "Impact of different PEGylation patterns on the long-term bio-stability of colloidal mesoporous silica nanoparticles," Journal of Materials Chemistry, vol.
Our core competencies center on liposomal manufacturing and protein PEGylation. We are located on the northwest side of Indianapolis, Indiana.
The molecule was modified with PEGylation technology to extend its duration of activity in the body.
While 5 or 9.6% PEG decreased spleen and liver accumulation compared to unPEGylated liposomes, spleen accumulation increased again with 13.7% PEG, indicating an upper limit to the effect of PEGylation. When PEG chains of different lengths were appended to the surface of immunoliposomes, as short (750 Da), intermediate (2000 Da), or long PEG (5000 Da), DSPE-PEG2000 was the best compromise for extended blood circulation and target binding in vivo.
Another approach in effective drug delivery is PEGylation technology for the modification of peptides, proteins and oligonucleotides (30).
For example, pegylation of the polymer backbone during the reduction step (or postsynthesis) is expected to increase hydrophilicity and reduce (renal) clearance times significantly .
The pharmacokinetics evaluation confirmed that PEGylation resulted in prolonged nanoparticle circulation and reduced DOX clearance rate.
Nektar Therapeutics (Nasdaq: NKTR), a biopharmaceutical company developing novel therapeutics based on its PEGylation and advanced polymer conjugation technology platforms, has today reported its financial results for the first half of 2012.
PEGylation of capsules has also been proposed on the hypothesis that protein adsorption, a prerequisite for an inflammatory response and consequent fibrous overgrowth, can be minimized or even prevented by steric repulsion (67) generated from the encapsulation of the membrane in a negatively charged layer.
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- Pegylated Granulocyte Colony Stimulating Factor
- Pegylated interferon alfa-2a
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- Pegylated interferon-alpha-2a
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- Pegylated Liposomal Doxorubicin
- Pegylated Liposomal Doxorubicin Hydrochloride
- Pegylated Liposome Encapsulated Cisplatin
- Pegylated Liposome Encapsulated Doxorubicin
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