Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36
with the reproductive system.
Another possible mechanism is a potential influence of adipokines leptin, adiponectin, ghrelin PYY3-36
and resistin on energy homeostasis, all of which can affect female fertility [39, 40].
Obinepitide: Obinepitide is a synthetic analog of two naturally occurring human hormones: PYY3-36
and pancreatic polypeptide.
Dr Shu Lin, Dr Yan-Chuan Shi and Professor Herbert Herzog, from Sydney's Garvan Institute of Medical Research, have shown that when mice are injected with PYY3-36
and PP, they eat less, gain less fat, and tend not to develop insulin-resistance, a precursor to diabetes.
They also had significantly higher levels of another hormone, called PYY3-36
, which signals we are full.
Emispherea[euro](tm)s proprietary oral SNAC (Sodium N-[8-(2-hydroxybenzoyl) Amino] Caprylate) additive, in combination with the digestive hormones GLP-1 and PYY3-36
, was successful in reducing food intake and increasing satiety in healthy male subjects in the appetite suppression study.
A peptide (gut hormone) that inhibits food intake by actions on the hypothalamus, with secondary effects on glucose metabolism.
NASDAQ: EMIS) has announced data from a clinical study designed to assess the effect of oral administration of two peptides, GLP-1 and PYY3-36
, utilizing Emisphere's Eligen Technology on appetite suppression.
Nasdaq: NSTK) has started a Phase II clinical trial evaluating the Company's PYY3-36
nasal spray in obese patients.
results from a joint collaboration between Imperial College London and Oregon Health & Science University, partly funded by Wellcome Trust, who also holds an equity position in Thiakis.
The hormone - called PYY3-36
- is produced naturally but overweight people only have a third of the amount seen in the lean.
The drug, a protein called PYY3-36
, would have to be injected to avoid it being destroyed by the stomach's digestive juices.