Metformin is perhaps the most widely used oral glucose-lowering drug, known to have anti-malarial properties.24 Paludrine
, a drug structurally similar to metformin, was used as a potent anti malarial, and was noted to be effective even in quinine-resistant cases.25
Between 1958 and 1962, the DRV employed acriquine (quinacrine), plasmocid (antimalarine and rhodoquine) and paludrine
(proguanil), drugs mostly available during the First Indochina War.
Presently, first-line clinical management of sickle cell anemia includes use of hydroxyurea, folic acid and amino acids supplementation (as nutritional supplements), penicillin prophylaxis (helps prevent infection), and antimalarial prophylaxis (helps prevent malaria attack), for example, paludrine
in varying doses in childhood, adulthood, and pregnancy.
Alliance Pharmaceuticals Limited, a wholly owned subsidiary of Alliance Pharma, is paying an initial GBP4.2m to purchase the brands Paludrine
, Avloclor and Savarine from AstraZeneca UK Limited.
ICI's many former successes include developing anti-malarial drug Paludrine
and the invention of Polythene and Perspex.
It was credited with developing the antimalarial drug Paludrine
and for inventing Polythene and Perspex, seeing some of its scientists awarded the Nobel Prize.
In the 1940s, the company's pharmaceutical department invented Paludrine
, the first synthetic treatment against malaria.
(proguanil) as a malarial prophylactic amongst African labour in Kenya.
an antimalarial treatment had a major impact on world health.