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Related to Paracrine signaling: endocrine signaling


 (păr′ə-krĭn′, -krēn′)
Of or relating to the release of locally acting substances from endocrine cells.

[German parakrin : Greek para-, para- + Greek krīnein, to separate; see krei- in Indo-European roots.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Physiology) relating to a hormone whose release only affects tissue surrounding the gland that secreted it
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
The research team concluded that "feto-maternal and maternalafetal trafficking of exosomes indicative of paracrine signaling during pregnancy.
In terms of regenerative medicine, iMSCs acquired a secretome similar to that of primary MSCs, thus highlighting their ability to act via paracrine signaling.
Stem cells and stem cell therapy work by paracrine signaling to create the appropriate healing environment to restore tissue.
PGR regulates implantation, decidualization, and glandular development via a complex paracrine signaling network [3-5].
The activity of PB4188 was unaffected by increasing concentrations of HRG, the ligand for HER3 which mirrors the autocrine or paracrine signaling environment of the tumor, in contrast to monoclonal antibodies against the same targets, tested as single agents or in combination.
Roarty, "Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity?," (in Eng), Breast Cancer Res, vol.
ADAM17 releases extracellular domains of transmembrane proteins to produce soluble bioactive signaling proteins taking part in autocrine (activation of receptors within the same epithelial cell layer) and paracrine signaling (activation of cellular receptors on underlying neighboring cells, also termed transactivation).
Proposed paracrine signaling with TNIP1 regulation in psoriasis where nonimmune cells are keratinocytes [111].
Differentiation and paracrine signaling have both been implicated with mechanisms by which MSCs improve tissue repair.
However, estrogen does not directly act on endometrial mesenchymal stem cells, but influence stem cells via paracrine signaling to promote endometrium regrowth.[33] Moreover, TAZ can be activated by estrogen.[34] These observations suggested that estrogen regulates endometrial stem cell differentiation via the Hippo pathway.
Heasley, "Autocrine and paracrine signaling through neuropeptide receptors in human cancer," Oncogene, vol.
Blit et al., "Human Wharton's jelly mesenchymal stem cells promote skin wound healing through paracrine signaling," Stem Cell Research and Therapy, vol.