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Related to Paratope: agretope, Idiotope


A small molecular region of an antigen that binds to a particular antibody or antigen receptor on a T cell; an antigenic determinant. A single antigen can have multiple epitopes.

[epi- + Greek topos, place, spot.]


(Medicine) the site on an antigen at which a specific antibody becomes attached


(ˈɛp ɪˌtoʊp)

a site on an antigen at which an antibody can bind, the molecular arrangement of the site determining the specific combining antibody. Also called antigenic determinant .
[1970–75; epi- + -tope < Greek tópos place; compare topo-]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.epitope - the site on the surface of an antigen molecule to which an antibody attaches itself
immunology - the branch of medical science that studies the body's immune system
site, situation - physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides"
antigen - any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
References in periodicals archive ?
Two of the star services are antibody-antigen complex modeling and paratope characterization.
If the L-DOPA antigen were specifically bound to the antibody after this pretreatment, it would mask the antibody's paratope, preventing it from generating false-positive binding events to epitopes in the fixed tissue; and we would expect a negative staining result in subsequent fluorescence imaging.
Wingfield, "A cell-penetrating antibody fragment against HIV-1 Rev has high antiviral activity: Characterization of the paratope," The Journal of Biological Chemistry, vol.
The presence of additional noncanonical cysteine residues in frameworks 2 and 4 and CDR loops defines a series of related VNAR isotypes or structurally distinct families with diverse paratope topologies capable of binding more cryptic or hidden epitopes [23-25].
The basis of this method is mutual affinity between antigens (epitope) and antibodies (paratope).
Vauterin et al., "Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain," The Journal of Biological Chemistry, vol.