substantia nigra

(redirected from Pars compacta)
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Related to Pars compacta: subthalamic nucleus, Nigrostriatal pathway

substantia ni·gra

 (nī′grə, nĭg′rə)
A layer of large pigmented nerve cells in the midbrain that produce dopamine and whose destruction is associated with Parkinson's disease.

[New Latin : Latin substantia, substance + Latin nigra, feminine of niger, black.]

substantia nigra

(səbˈstænʃə ˈnaɪɡrə)
(Anatomy) a layer of grey matter in the brain that produces dopamine and contains pigmented nerve cells, loss of which has been associated with Parkinson's disease
[C20: from Latin, literally: dark material]

sub•stan•ti•a ni•gra

(səbˈstæn ʃi ə ˈnaɪ grə, ˈnɪg rə)

n., pl. sub•stan•ti•ae ni•grae (sʌbˈstæn ʃiˌi ˈnaɪ gri, ˈnɪg ri) substantia ni•gras.
a deeply pigmented area of the midbrain containing dopamine-producing nerve cells.
[1880–85; < New Latin: black substance]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.substantia nigra - a layer of deeply pigmented grey matter in the midbrain; associated with the striate body; is involved in metabolic disturbances associated with Parkinson's disease and with Huntington's disease
neural structure - a structure that is part of the nervous system
mesencephalon, midbrain - the middle portion of the brain
References in periodicals archive ?
6-OHDA was injected into the right substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) of each group, except normal + NS, 60 days after the PX.
The triggering factor in the pathogenesis includes the progressive loss of dopaminergic neurons of substantia nigra pars compacta.
Dopamine from substantia nigra pars compacta and ventral tegmental area modify the activation in basal ganglia circuit by acting on striatum.
Excess iron is primarily detected in the substantia nigra pars compacta, where dopaminergic neurons are exposed to high levels of oxidative stress produced by mitochondrial disorders and dopamine metabolism.
4) Analysis of MRI images of midbrain in patients with Parkinson's disease shows narrowing of signal from pars compacta of midbrain.
It is primarily caused by the degenerative deletion through apoptosis of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) [1].
Research has confirmed that symptoms of PD are a result of progressive dopaminergic cell death in the substantia nigra pars compacta of the basal ganglia (Bergman & Deuschl, 2002).
Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that contain the binding site for glutamate, and mGlu4, specifically, is localized to presynaptic terminals in a region of the brain called the substantia nigra pars compacta (SNpc).
In addition, by treating JNK with a peptide inhibitor derived from a mitochondrial membrane protein, the team was able to induce a two-fold level of protection of neurons in the substantia nigra pars compacta, the brain region devastated by Parkinson's disease.
Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by the degeneration and progressive loss of dopaminergic neurons in the substantia nigra pars compacta.
A more accurate statement would be that dopamine is released by the substantia nigra pars compacta or the ventral tegmental area and activates five different types of receptors in the dorsal striatum, which is involved in motor control and habit learning, and in the nucleus accumbens, which is implicated in reward processing and in many other brain regions.

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