agonist

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ag·o·nist

 (ăg′ə-nĭst)
n.
1. Physiology A contracting muscle that is resisted or counteracted by another muscle, the antagonist.
2. A substance that can combine with a receptor on a cell to initiate signal transduction.
3. One involved in a struggle or competition.

[Late Latin agōnista, contender, from Greek agōnistēs, from agōn, contest; see agony.]

agonist

(ˈæɡənɪst)
n
1. (Physiology) any muscle that is opposed in action by another muscle. Compare antagonist2
2. a competitor, as in an agon
[C17: from Greek agōn agon]

ag•o•nist

(ˈæg ə nɪst)

n.
1. a person engaged in a contest, conflict, struggle, etc., esp. the protagonist in a literary work.
2. a person who is torn by inner conflict.
3. a contracting muscle whose action is opposed by another muscle. Compare antagonist (def. 3).
4. a chemical substance capable of activating a receptor to induce a full or partial pharmacological response. Compare antagonist (def. 5).
[1620–30; < Late Latin agōnista < Greek agōnistḗs contestant =agṓn agon + -istēs -ist]

ag·o·nist

(ăg′ə-nĭst)
A muscle that actively contracts to produce a desired movement. Compare antagonist.

agonist

one who contends for a prize in public games. — agonistic, agonistical, adj.
See also: Athletics
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.agonist - the principal character in a work of fictionagonist - the principal character in a work of fiction
antihero - a protagonist who lacks the characteristics that would make him a hero (or her a heroine)
2.agonist - someone involved in a contest or battle (as in an agon)agonist - someone involved in a contest or battle (as in an agon)
contestant - a person who participates in competitions
adversary, antagonist, opposer, resister, opponent - someone who offers opposition
3.agonist - a muscle that contracts while another relaxesagonist - a muscle that contracts while another relaxes; "when bending the elbow the biceps are the agonist"
antagonistic muscle - (physiology) a muscle that opposes the action of another; "the biceps and triceps are antagonistic muscles"
4.agonist - (biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction
drug - a substance that is used as a medicine or narcotic
biochemistry - the organic chemistry of compounds and processes occurring in organisms; the effort to understand biology within the context of chemistry
Translations
agonista
agonista
References in periodicals archive ?
This is based on the development of the strategy of conformational thermostabilisation of GPCRs developed in our lab that has resulted in the structure determination of 3 different GPCRs bound to either antagonists, partial agonists, full agonists and/or biased agonists.
The remainder of the compounds can be considered partial agonists with graded effects, with 4-OP being the most active (~80% of the transactivation seen with [E.
Partial agonists of 5-HT1A receptors have been the subject of investigation for the treatment of behavioral conditions.
Researchers have studied the effects of dopamine partial agonists (1)-agents that block the activities of the dopamine receptors (i.
In contrast, except for UK-14304, all of the imidazolines and guanidines were partial agonists in this system (right figure).
Prof David Nutt claims it is possible to replace all the benefits of alcohol with one chemical, partial agonists (PA), without any of the drawbacks.
beta]-Adrenoceptor blockers with partial agonist activity like pindolol approach the ideal combination for heart-rate control because diurnal tachycardia is reduced by virtue of the [beta]-blocking sympatholytic effects and nocturnal bradycardia is prevented by the sympathomimetic opposition of partial agonists to parasympathetic tone.