Antinuclear antibodies and anti-double stranded DNA were negative; the serum lactate, pyruvate, complement 3, complement 4, perinuclear
antineutrophil cytoplasmic antibody, cytoplasmic antineutrophil cytoplasmic antibody, and thyroid function tests were normal.
Koilocytes containing enlarged and irregular nuclei, perinuclear
halos, and coarse keratohyalin granules may be found in the granular and upper spinous layers.
Fibrillary astrocytes show perinuclear
rim of positivity.
Koilocytes, the hallmark of HPV infection, with raisin-like nuclear membranes and a perinuclear
halo (40x magnification).
dot-like CK20 positivity would be diagnostic for MCC, but a close look on CK20 staining revealed neoplastic cells that had diffuse cytoplasmic staining as well as neoplastic cells with perinuclear
dot-like staining [Figure 4].
The researchers found that HCV caused an accumulation of membrane phosopholipids but not neutral lipids and that cholesterol accumulated in the perinuclear
region of HCV-infected cells.
Additionally, phagocytic vacuoles with membranous residues and widened perinuclear
cisterna were observed in a few apoptotic cells (Figure 8h-inset).
Serological viral markers and antinuclear antibodies, anti-double stranded DNA, glomerular basement membrane antibody, cytoplasmic antineutrophil cytoplasm antibodies, and perinuclear
antineutrophil cytoplasm antibodies were negative while complements were within normal limits.
Coarse granular and perinuclear
antineutrophil cytoplasmic antibodies (ANCAs) can be detected in 38% to 50% of the patients.
Laboratory testing was significant only for a mildly elevated anti-proteinase-3 antibody (6.2; laboratory normal range < 3.5); anti-myeloperoxidase antibody test, cytoplasmic and perinuclear
anti-neutrophil cytoplasmic antibody staining on immunofluorescence, and a nasal mucosa biopsy were all negative, and anti-nuclear antibody titers were within normal limits; hsCRP was mildly elevated (Fig.
They contain perinuclear
vacuoles in fascicular growth pattern and consist of storiform and epithelioid cells.
Additionally, vinculin is expressed in the perinuclear
region at day 1 and relocates apically at day 6 of pregnancy as seen in Figs.