Phenanthridine


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Phe`nan´thri`dine


n.1.(Chem.) A nitrogenous hydrocarbon base, C13H9N, analogous to phenanthrene and quinoline.
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The simple chromophors quinoline, isoquinoline or phenanthridine will give access to new classes of compounds.
Malka Cohen-Armon found that the stroke drug - a member of a family of phenanthridine derivatives developed by an American drug company - worked to kill cancer in mice which had been implanted with human breast cancer cells.
low forward scatter, and low phenanthridine and carbocyanine fluorescence).
Led by Professor Cohen-Armon of Tel-Aviv University, the researchers found that potent phenanthridine derived polyADP-ribose polymerase (PARP) inhibitors efficiently eradicate MCF-7 and MDA231 breast cancer cells without impairing normal proliferating cells, such as human epithelial cells (MCF-10A), nor normal non-proliferating cells, such as neurons and cardiomyocytes.
Quantitative photochemical DNA cleaving studies with nitrogen onium salts were performed using potential DNA intercalators based on the quinoline, isoquinoline and phenanthridine skeletons.